当一个细胞接触并快速蚕食另一个细胞时,就会发生胞浆增生,其特征是活细胞之间的接触和具有功能完整性的膜碎片的快速转移。许多免疫细胞参与了这个过程,比如T细胞,B细胞,NK细胞,APC。转移的膜分子包括MHC分子,共刺激分子,受体,抗原,等。越来越多的研究表明,胞管病在免疫系统及相关疾病的发生中起着重要作用。因此,巨胞症是免疫系统的朋友还是敌人令人费解,其确切机制尚未完全阐明。这里,我们提供了一个完整的视图,获得的研究结果之间的联系,在thogoycytesysis和免疫系统。
Trogocytosis occurs when one cell contacts and quickly nibbles another cell and is characterized by contact between living cells and rapid transfer of membrane fragments with functional integrity. Many immune cells are involved in this process, such as T cells, B cells, NK cells, APCs. The transferred membrane molecules including MHC molecules, costimulatory molecules, receptors, antigens, etc. An increasing number of studies have shown that trogocytosis plays an important role in the immune system and the occurrence of relevant diseases. Thus, whether trogocytosis is a friend or foe of the immune system is puzzling, and the precise mechanism underlying it has not yet been fully elucidated. Here, we provide an integrated view of the acquired findings on the connections between trogocytosis and the immune system.