背景:登革热是人类最普遍的蚊媒病毒性疾病。血小板指数(PI)由细胞计数器给出,但通常未报告,这可能是由于对这些参数的实用性认识不足。
目的:本研究旨在比较登革热患者的PIs,以评估其在住院时间和血小板输注需求等结局中的作用。
方法:在三级护理中心进行的前瞻性观察研究,Thrissur,喀拉拉邦.
方法:对一组250名登革热患者进行了为期18个月的研究。血小板参数(血小板计数,平均血小板体积[MPV],血小板分布宽度[PDW],血小板大细胞比率[PLCR],用SysmexXN-1000测量血小板计数[PCT]和未成熟血小板分数[IPF]),每24小时随访一次。临床特征,收集住院时间和血小板输注需求详情.
方法:独立t检验,卡方检验,卡尔皮尔逊相关系数。
结果:总样本量为250。研究显示PDW和MPV正常,低血小板计数和PCT,登革热患者的PLCR和IPF较高。PIs有显著差异(较低的血小板计数和PCT,更高的MPV,PDW,PLCR,和IPF)在基于血小板输注的登革热患者之间进行比较。
结论:PIs可作为登革热诊断和预测结果的预测工具。低血小板计数和PCT,高PDW,MPV,PLCR,发现输血登革热患者的IPF和IPF具有统计学意义。临床医生需要对这些指标的实用性和局限性敏感,并合理化登革热中红细胞和血小板输注的需求。
BACKGROUND: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.
OBJECTIVE: This
study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.
METHODS: Prospective observational
study in a tertiary care center, Thrissur, Kerala.
METHODS: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.
METHODS: Independent t-test, Chi-square test, Karl Pearson correlation coefficient.
RESULTS: A total of sample size was 250. The
study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.
CONCLUSIONS: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.