HypermobileEhlersDanlos综合征(hEDS)是一种多方面的疾病,主要由于未知原因而难以诊断和管理。关于hEDS的研究继续发展,但是当越来越多的证据补充临床实践时,将实现切实的进步。这篇批判性的文献综述旨在激发对发病机理的横向思考,hEDS的诊断和管理。目前的EhlersDanlos综合征国际分类法对hEDS提出了更严格的诊断标准,针对有症状的关节过度活动的病症,它具有一揽子类别(高活动频谱障碍),但不符合hEDS诊断标准。有人会争辩说,hEDS是遗传性结缔组织疾病和/或获得性肌肉骨骼疾病的另一种全面分类,没有明确的分子基础。随着科学研究的进展,以适应经过验证和/或废除的假设,hEDS中过多的未知因素继续挑战医疗保健结果和护理经验.
Hypermobile Ehlers Danlos Syndrome (hEDS) is a multifaceted disorder that is difficult to diagnose and manage primarily due to the unknown causes. Research on hEDS continues to evolve but tangible progress will be realized when the growing body of evidence compliments clinical practice. This critical
review of the literature aims to stimulate lateral thinking about the pathogenesis, diagnosis and management of hEDS. The current international classification of Ehlers Danlos Syndrome introduced stricter diagnostic criteria for hEDS, which bore a blanket category (hypermobility spectrum disorders) for conditions presenting with symptomatic joint hypermobility, but do not match the hEDS diagnostic criteria. One would argue hEDS is another all-encompassing classification for heritable connective tissue disorders and or acquired musculoskeletal conditions without a definitive molecular basis. As scientific research progresses to accommodate validated and or annulled hypotheses, the plethora of unknowns in hEDS continue to challenge healthcare outcomes and care experiences.