最近,已经描述了高危型人乳头瘤病毒(hrHPV)及其与食管癌(EC)风险增加的关联的流行病学证据。然而,此类病毒是否参与EC的发病机制在文献中仍无定论.因此,我们的目的是通过病例-对照模式的回顾性研究,阐明初诊EC病例中HPV感染的流行病学特征,并验证这种与医院对照患者的相关性.这里,我们报道,HPVDNA的总体患病率与EC的风险增加有统计学关联(OR,3.3;95%CI,2.5-4.3)。有趣的是,胃食管反流病(GERD)的病史构成,并与HPV患病率显着相关(校正OR,4.6;95%CI,2.2-9.5)。此外,我们在公共数据库中的荟萃分析还表明,HPV感染和EC风险之间的组合OR和95%CI分别为3.31和2.53-4.34,具有显著的异质性(I2=78%)。地理研究的变化,组织类型,检测方法仍然是异质性的潜在预测因素。此外,未观察到发表偏倚和敏感性分析,结果显示结果稳定。总的来说,我们指定了最近的流行病学证据来验证分布的HPV,这可能在统计学上与EC风险增加相关。然而,我们还需要更多具有更大样本量的高质量研究来进一步验证HPV和EC之间的联系.
Recently, epidemiological evidence of high-risk human papillomavirus (hrHPV) and its association with the increasing risk of esophageal cancer (EC) have been described. However, the involvement of such a virus in the pathogenesis of EC is still inconclusive in the literature. Therefore, our objective was to clarify the epidemiology of HPV infections in primarily diagnosed EC cases and validate this correlation with hospital-based control patients using a retrospective
study with a case-control model. Here, we reported that the overall prevalence of HPV DNA was statistically associated with an increased risk of EC (OR, 3.3; 95% CI, 2.5-4.3). Interestingly, a history of gastroesophageal reflux disease (GERD) was constituted and significantly associated with HPV prevalence (adjusted OR, 4.6; 95% CI, 2.2-9.5). Furthermore, our meta-analysis in public databases also indicated that the combined OR and 95% CI between HPV infection and EC risk were 3.31 and 2.53-4.34, respectively, with significant heterogeneity (I2 = 78%). Variations in the geographic
study, tissue type, and detection method remain potential predictors of heterogeneity. In addition, publication bias and sensitivity analysis were not observed, and the results exhibited stable outcomes. Collectively, we specify the recent epidemiological evidence in a validation of the distributed HPV, which might be statistically associated with an increased risk of EC. However, additional high-quality studies with larger sample sizes are needed to further verify the link between HPV and EC.