■2014年首次报告人类感染高致病性禽流感A(H5N6)病毒。从那时起到2023年6月30日,全球报告了85例确诊的A(H5N6)感染病例。
■为了解决目前在人类A(H5N6)感染总体流行病学知识方面的差距,描述了2014年2月至2023年6月中国人感染H5N6的流行病学特征。
■考虑到人类感染A(H5N6)病毒的严重程度(病死率:39%),从2021年到现在,病例报告的频率增加,缺乏对所有病例的全面流行病学分析,我们进行了多病例描述性分析和文献综述,以创建报告的人类病例的流行病学概况.病例数据是通过文献检索和使用加拿大公共卫生局国际监测和评估工具(IMAT)捕获的官方情报来源获得的,包括世界卫生组织的事件信息网站帖子。
■大多数人类A(H5N6)病例来自中国(中国:84;老挝:1),伴随着严重的健康结果,包括住院和死亡,在高危人群中报告。大多数病例(84%)报告在发病前与鸟类接触。全年都发现了病例,在温暖的月份,疾病发病率略有下降。
■由于A(H5N6)继续循环并引起严重疾病,监测和及时的信息共享对于制定和实施有效的公共卫生措施以减少额外人类感染的可能性非常重要。
UNASSIGNED: The first human infection with highly pathogenic avian influenza A(H5N6) virus was reported in 2014. From then until June 30, 2023, 85 human cases with confirmed A(H5N6) infection have been reported worldwide.
UNASSIGNED: To address the present gap in knowledge of the overall epidemiology of human A(H5N6) infections, the epidemiological characteristics of human infection with A(H5N6) in China from February 2014 to June 2023 are described.
UNASSIGNED: Considering the severity of
human infections with A(H5N6) virus (
case fatality rate: 39%), the increased frequency of
case reports from 2021 to present day, and lack of comprehensive epidemiologic analysis of all cases, we conducted a multiple-
case descriptive analysis and a literature review to create an epidemiologic profile of reported
human cases.
Case data was obtained via a literature search and using official intelligence sources captured by the Public Health Agency of Canada\'s International Monitoring and Assessment Tool (IMAT), including Event Information Site posts from the World Health Organization.
UNASSIGNED: Most human A(H5N6) cases have been reported from China (China: 84; Laos: 1), with severe health outcomes, including hospitalization and death, reported among at-risk populations. The majority (84%) of cases reported contact with birds prior to illness onset. Cases were detected throughout the course of the year, with a slight decrease in illness incidence in the warmer months.
UNASSIGNED: As A(H5N6) continues to circulate and cause severe illness, surveillance and prompt information sharing is important for creating and implementing effective public health measures to reduce the likelihood of additional human infections.