背景:血脂水平升高是动脉粥样硬化和心血管疾病的主要原因。几项研究使用姜作为降脂剂。
目的:本系统综述和荟萃分析的目的是阐明补姜对血脂参数的影响。
方法:PubMed,Scopus,科学直接,直到2017年5月,系统搜索了ISIWebofScience和GoogleScholar,以寻找临床试验,这些临床试验检查了补充生姜对成年参与者脂质参数水平的影响。提取了血脂的手段和异质性的潜在来源。应用亚组分析找出研究间异质性的潜在来源。
结果:共有12项试验(586名参与者)纳入荟萃分析。汇总分析表明,补充生姜可降低三酰甘油(TAG)(-17.59mg/dl;95%CI:-29.32至-5.87)和低密度脂蛋白胆固醇(LDL-C)(-4.90mg/dl;95%CI:-22.30至-6.17)。生姜对总胆固醇(TC)无显著影响(-5.13mg/dl,95%CI:-11.05至0.78;P=0.089)和高密度脂蛋白胆固醇(HDL-C)(2.18mg/dl,95%CI:-0.08至4.45;P=0.059)。由于研究间的异质性很高,研究按生姜剂量分类。分层分析表明,在使用≤2g/天生姜的研究中,TC(-12.26mg/dl;95%CI:-22.37至-2.16)和TAG(-38.42mg/dl;95%CI:-57.01至-19.82)显着降低。然而,在>2g/天生姜的试验中未观察到类似的显着效果。使用≤2g/天的研究和使用>2g/天的生姜的试验均未显示LDL-C或HDL-C的显着变化。
结论:本系统综述和荟萃分析表明生姜对TAG和LDL-C具有良好的作用。此外,结果表明,低剂量生姜(≤2g/天)对TAG和TC的降低作用更大。需要进一步的大规模和更好的设计研究来证实这一结果。
BACKGROUND: Elevated levels of blood lipids are a major cause of atherosclerosis and consequently cardiovascular disease. Several studies used ginger as a lipid lowering agent.
OBJECTIVE: The aim of the present systematic
review and meta-analysis was to clarify the effect of ginger supplementation on lipid parameters.
METHODS: PubMed, Scopus, Science Direct, ISI Web of Science and Google Scholar were systematically searched until May 2017 to find clinical trials which examined effect of ginger supplementation on level of lipid parameters in adult participants. Means for blood lipids and potential sources of heterogeneity were extracted. A subgroup analysis was applied to find out potential sources of inter-study heterogeneity.
RESULTS: A total of 12 trials (586 participants) were included in the meta-analysis. Pooled analysis suggested that ginger supplementation reduced triacylglycerol (TAG) (-17.59 mg/dl; 95% CI: -29.32 to -5.87) and low density lipoprotein cholesterol (LDL-C) (-4.90 mg/dl; 95% CI: -22.30 to -6.17). Ginger had no significant effect on total cholesterol (TC) (-5.13 mg/dl, 95% CI: -11.05 to 0.78; P = 0.089) and high density lipoprotein cholesterol (HDL-C) (2.18 mg/dl, 95% CI: -0.08 to 4.45; P = 0.059). As inter-study heterogeneity was high, studies were classified by ginger dosage. Stratified analysis showed a significant reduction in TC (-12.26 mg/dl; 95% CI: -22.37 to -2.16) and TAG (-38.42 mg/dl; 95% CI: -57.01 to -19.82) in studies which used ≤2 g/day of ginger. However, a similar significant effect was not observed in trials with >2 g/day of ginger. Neither studies which used ≤2 g/day nor trials which used >2 g/day of ginger showed significant changes in LDL-C or HDL-C.
CONCLUSIONS: The present systematic
review and meta-analysis suggests that ginger had a favorable effect on TAG and LDL-C. Also, the result revealed that low dose of ginger (≤2 g/day) had greater lowering impact on TAG and TC. Further studies with large-scale and better design are needed to confirm this result.