分子和解剖病理学的迅速发展极大地改善了我们对肝细胞腺瘤的理解。其中的原则是临床相关的,基于组织学的分类,可识别出恶性转化风险最大的肝腺瘤。这种新的分类系统已导致对肝腺瘤主要亚型的普遍共识。然而,关于如何将较不常见类型的肝腺瘤纳入分类系统以及如何将腺瘤亚型纳入临床治疗仍存在争议。本文对腺瘤是如何分类的进行了深入的综述,专注于当前的基本原理,共识,和争议。
Rapid advances in molecular and anatomic pathology have greatly improved our understanding of hepatocellular adenomas. Principle among them is a clinically relevant, histology-based classification that identifies hepatic adenomas at greatest risk for malignant transformation. This new classification system has led to general
consensus on the major subtypes of hepatic adenomas. However, controversy remains regarding how to incorporate less common types of hepatic adenomas into the classification system and how to incorporate adenoma subtyping into clinical care. This article provides an in-depth review of how adenomas are classified, with a focus on the current rationale, the
consensus, and controversies.