Hepatocarcinoma

肝癌
  • 文章类型: Journal Article
    肝细胞癌是最常见的原发性恶性肝肿瘤,最常见于慢性肝病。肝移植是一种治愈性治疗选择,是一种理想的解决方案,因为它解决了慢性潜在的肝脏疾病,同时消除了恶性病变。然而,由于器官短缺,根据临床指南,这种治疗方法只能应用于精心选择的患者。人工智能是一种新兴技术,在医学中具有多种应用,对与医学成像一起工作的领域具有优势,比如放射学.在这些技术的帮助下,费力的任务可以自动化,并且可以基于像素级分析开发新的病变成像标准。我们的目标是审查可以实施的AI应用程序,以更好地对肝移植候选人进行分层。论文分析了应用AI进行肝脏分割,脂肪变性的评估,肌肉减少症评估,病变检测,分割,和表征。肝移植是慢性肝病背景下肝细胞癌患者的最佳治疗方法。此外,AI可以为改善肝移植候选人的管理提供解决方案,以提高生存率。
    Hepatocellular carcinoma is the most common primary malignant hepatic tumor and occurs most often in the setting of chronic liver disease. Liver transplantation is a curative treatment option and is an ideal solution because it solves the chronic underlying liver disorder while removing the malignant lesion. However, due to organ shortages, this treatment can only be applied to carefully selected patients according to clinical guidelines. Artificial intelligence is an emerging technology with multiple applications in medicine with a predilection for domains that work with medical imaging, like radiology. With the help of these technologies, laborious tasks can be automated, and new lesion imaging criteria can be developed based on pixel-level analysis. Our objectives are to review the developing AI applications that could be implemented to better stratify liver transplant candidates. The papers analysed applied AI for liver segmentation, evaluation of steatosis, sarcopenia assessment, lesion detection, segmentation, and characterization. A liver transplant is an optimal treatment for patients with hepatocellular carcinoma in the setting of chronic liver disease. Furthermore, AI could provide solutions for improving the management of liver transplant candidates to improve survival.
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  • 文章类型: Consensus Development Conference
    乙型肝炎病毒(HBV)感染仍然是一个全球性的公共卫生问题。乙肝疫苗接种是降低乙肝病毒发病率的最有效手段。尽管在过去的几年中,慢性乙型肝炎的治疗没有新的临床进展,不断变化的流行病学和当前对自然史的见解,诊断工具和治疗适应症使得有必要更新2012年出版的西班牙肝脏研究协会关于乙型肝炎感染治疗的共识文件的前版。当前文件更新了慢性乙型肝炎的管理。选择的治疗方法是长期服用具有高耐药性屏障的核苷(t)ide类似物(恩替卡韦,替诺福韦或替诺福韦艾拉酚胺)。聚乙二醇干扰素可能是非晚期肝病患者的一种选择,但由于疗效低,耐受性差,其适用性有限。必须监测所有患者进展为晚期肝病和肝细胞癌发展的风险。
    Hepatitis B virus (HBV) infection remains a global public health problem. HBV vaccination is the most effective tool to reduce the incidence of HBV disease. Despite there has not been new clinical developments for the treatment of chronic hepatitis B in the last few years, changing epidemiology and current insights on natural history, diagnostic tools and therapy indications make necessary an update of the former version of the consensus document of the Spanish Association for Study of the Liver on the treatment of hepatitis B infection published in 2012. The current document updates the management of chronic hepatitis B. The treatment of choice is the long-term administration of a nucleos(t)ide analogue with high barrier to resistance (entecavir, tenofovir or tenofovir alafenamide). Pegylated interferon may be an option in patients with non-advanced liver disease, but its applicability is limited due to the low efficacy and poor tolerability. All patients must be monitored for the risk of progression to advanced liver disease and development of hepatocellular carcinoma.
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  • 文章类型: Consensus Development Conference
    The goal of the Spanish Liver Transplantation Society (La Sociedad Española de Trasplante Hepático) is to promote and create consensus documents about current topics in liver transplantation with a multidisciplinary approach. To this end, on October 20, 2016, the 6th Consensus Document Meeting was held, with the participation of experts from the 24 authorized Spanish liver transplantation programs. This Edition discusses the following subjects, whose summary is offered below: 1) limits of simultaneous liver-kidney transplantation; 2) limits of elective liver re-transplantation; and 3) liver transplantation after resection and hepatocellular carcinoma with factors for a poor prognosis. The consensus conclusions for each of these topics is provided below.
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  • 文章类型: Consensus Development Conference
    The goal of the Spanish Liver Transplantation Society (La Sociedad Española de Trasplante Hepático) is to promote and create consensus documents about current topics in liver transplantation with a multidisciplinary approach. To this end, on October 20, 2016, the 6th Consensus Document Meeting was held, with the participation of experts from the 24 authorized Spanish liver transplantation programs. This Edition discusses the following subjects, whose summary is offered below: 1) limits of simultaneous liver-kidney transplantation; 2) limits of elective liver re-transplantation; and 3) liver transplantation after resection and hepatocellular carcinoma with factors for a poor prognosis. The consensus conclusions for each of these topics is provided below.
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  • 文章类型: Consensus Development Conference
    With the aim to promote the elaboration of consensus documents on state of the art topics in liver transplantation with multidisciplinary management, the Spanish Society for Liver Transplantation (SETH) organized the V Consensus Meeting with the participation of experts from all the Spanish liver transplant programs. In this edition, the following topics were revised, and we present the summary: 1. High-risk receptors; 2. Immunosuppression scenarios; and 3. Management of the patient with hepatocarcinoma in the waiting list.
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  • 文章类型: Journal Article
    With the aim to promote the elaboration of consensus documents on state of the art topics in liver transplantation with multidisciplinary management, the Spanish Society for Liver Transplantation (SETH) organized the V Consensus Meeting with the participation of experts from all the Spanish liver transplant programs. In this edition, the following topics were revised, and we present the summary: 1. High-risk receptors; 2. Immunosuppression scenarios; and 3. Management of the patient with hepatocarcinoma in the waiting list.
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