■关于丙型肝炎病毒(HCV)感染是否与结直肠癌(CRC)相关仍存在不确定性。本研究旨在通过队列研究的系统评价和荟萃分析来探讨HCV感染与CRC之间的潜在关联。
■PubMed,Embase,和WebofScience从成立之初到2023年10月进行了系统搜索,以寻找HCV感染与CRC风险之间关联的相关队列研究.随机效应,使用通用逆方差法计算HCV感染患者CRC结局的风险比(HR)和95%置信区间(CI).我们还进行了亚组和敏感性分析。
■本荟萃分析共纳入了8项队列研究,涉及1,939,164名参与者。荟萃分析的结果表明,HCV与发生CRC的风险之间没有统计学上的显着关联(HR=0.99,95%CI:0.82-1.88,p=0.88),具有较低的统计异质性(I2=28%,p=0.20)。根据研究设计进行的亚组分析,HCV感染的诊断,和出版年份产生了类似的结果。基于研究领域的亚组分析显示,在亚洲,HCV感染与CRC风险之间没有显着关联(n=2,HR=0.96,95%CI:0.71-1.29,p=0.79;I2=26%),欧洲(n=3,HR=1.06,95%CI:0.83-1.37,p=0.63;I2=0%),和北美(n=2,HR=1.10,95%CI:0.87-1.38,p=0.44;I2=0%);然而,在大洋洲发现负相关(n=1,HR=0.43,95%CI:0.22-0.84,p=0.01)。敏感性分析进一步加强了我们结论的稳定性。
■我们基于队列的荟萃分析显示,没有足够的证据支持HCV感染与CRC风险增加之间的关联。为了更清楚地了解这两个条件之间的潜在关联,开展大型活动将是有益的,精心设计,考虑不同种族人群和潜在混杂因素的高质量前瞻性队列研究。系统审查注册:PROSPERO,标识符[CRD42023472688],https://www.crd.约克。AC.uk/prospro/display_record.php?ID=CRD42023472688。
UNASSIGNED: There is still uncertainty regarding whether hepatitis C virus (HCV) infection is associated with colorectal cancer (CRC). This study aims to investigate the potential association between HCV infection and CRC through a systematic
review and meta-analysis of cohort studies.
UNASSIGNED: PubMed, Embase, and Web of Science were systematically searched from the beginning of their inception to October 2023 to find relevant cohort studies on the association between HCV infection and CRC risk. The random-effect, generic inverse variance method was used to calculate the hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC outcome among individuals with HCV infection. We also performed subgroup and sensitivity analysis.
UNASSIGNED: A total of 8 cohort studies involving 1,939,164 participants were included in this meta-analysis. The result from the meta-analysis suggested that there was no statistically significant association between HCV and the risk of developing CRC (HR = 0.99, 95% CI: 0.82-1.88, p = 0.88) with low statistical heterogeneity (I2 = 28%, p = 0.20). Subgroup analyses that were conducted based on study design, diagnosis of HCV infection, and publication year yielded similar results. Analyses of subgroups based on study areas revealed that there was no significant association between HCV infection and CRC risk in Asia (n = 2, HR = 0.96, 95% CI: 0.71-1.29, p = 0.79; I2 = 26%), Europe (n = 3, HR = 1.06, 95% CI: 0.83-1.37, p = 0.63; I2 = 0%), and North America (n = 2, HR = 1.10, 95% CI: 0.87-1.38, p = 0.44; I2 = 0%); however, a negative correlation was found in Oceania (n = 1, HR = 0.43, 95% CI: 0.22-0.84, p = 0.01). Sensitivity analysis further reinforce the stability of our conclusion.
UNASSIGNED: Our cohort-based meta-analysis showed insufficient evidence to support the association between HCV infection and an increased risk of CRC. To gain a clearer insight into the potential association between these two conditions, it would be beneficial to conduct large, well-designed, high-quality prospective cohort studies that consider different ethnic populations and potential confounding factors.Systematic
review registration: PROSPERO, identifier [CRD42023472688], https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023472688.