这项研究介绍了一例15岁的欧洲Shorthair雌性猫的原发性肝肌纤维母细胞瘤。猫显示肝酶(丙氨酸转氨酶和天冬氨酸转氨酶)逐渐增加,腹部超声显示肿瘤位于肝脏的左外侧叶内。手术切除肿瘤并送去组织病理学检查。组织病理学检查显示肿瘤由具有低有丝分裂计数的同质梭形细胞组成,拥挤在外围,门户和小叶间空间,肝细胞和胆管的截留。免疫组织化学显示肿瘤细胞表达波形蛋白和α-SMA,并且对结蛋白和细胞角蛋白呈阴性。根据组织学和免疫组织化学特征,以及与人类和动物中类似实体的一些相似之处,该肿瘤被归类为源自肝脏的肌纤维母细胞肿瘤。
This study presents a
case of a primary hepatic myofibroblastic tumour in a 15-year-old European Shorthair female cat. The cat showed a gradual increase in liver enzymes (alanine aminotransferase and aspartate aminotransferase), and an abdominal ultrasound revealed a tumour located within the left lateral lobe of the liver. The tumour was surgically excised and sent for histopathology. Histopathological examination showed that the tumour was composed of homogeneous fusiform cells with low mitotic count, crowded within the perisinusoidal, portal and interlobular spaces, and entrapment of hepatocytes and bile ducts. Immunohistochemistry revealed that the tumour cells expressed vimentin and α-SMA, and were negative to desmin and cytokeratins. Based on the histological and immunohistochemical features, as well as some similarities with analogous entities in humans and animals, the tumour was classified as a myofibroblastic neoplasm originating from the liver.