■从世界不同国家到欧洲国家的流动和移民流动正在增长,包括法国,特别是地中海盆地。这项研究旨在调查蒙彼利埃医院(法国)的门诊患者/住院患者中血红蛋白(Hb)变体的存在,这些患者已进行了HbA1c测定,并已告知出生国。
■这是一项2016年1月至2020年12月的回顾性研究,基于所有高效液相色谱(HPLC)色谱图(TosohBioscienceHLC-723G8),在HbA1c测量过程中发出可疑Hb变异警报。将相应的样品系统地送至血液学实验室以确认和鉴定Hb变体。患者病史,从每个病历中提取临床和人口统计学数据.使用XLSTAT®软件进行统计分析,版本2016.06.35661。
■三百六十三例患者被证实患有Hb变异,表现出17种不同的Hb谱,强调糖化血红蛋白(HbA1c)作为检测步骤的关键作用。在法国南部人群中,Hb变异的患病率为0.71%,β-珠蛋白变体的频率最高(n=342/363;即,94.2%),包括最常见的:S,C,E,和D在200/342(58.5%),83/342(24.3%),29/342(8.5%),和11/342(3.2%),分别。在Hb变异的患者中,几乎一半(165/363;即45.4%)出生在非洲大陆,摩洛哥占主导地位(32/165;即19.3%)和阿尔及利亚(29/165;即,17.5%)。
■HbA1c测定法是检测Hb变体的有用工具。血红蛋白病是当前法国人口中的公共卫生问题,这是一个多种族社会。尽管我们的研究是单一中心的,我们注意到法国南部的Hb变异频率很高,这强调了在整个人群中筛查Hb变异的重要性。
UNASSIGNED: Mobility and migration flows are growing from different countries of the world to European countries, including France and in particular the Mediterranean basin. This
study aimed to investigate the presence of hemoglobin (Hb) variants in outpatients/inpatients of the Montpellier Hospital (France) in whom an HbA1c assay had been performed and for which the country of birth had been informed.
UNASSIGNED: This is a retrospective
study from January 2016 to December 2020 based on all high-performance liquid chromatography (HPLC) chromatograms (Tosoh Bioscience HLC-723G8) having an alarm of suspected Hb variant during HbA1c measurement. The corresponding samples were systematically sent to the hematology laboratory for confirmation and identification of Hb variant. Patient\'s medical history, clinical and demographic data were extracted from each medical chart. Statistical analyses were performed using XLSTAT® software, version 2016.06.35661.
UNASSIGNED: Three hundred sixty-three patients were confirmed with Hb variant exhibiting 17 different Hb profiles, highlighting the pivotal role of glycated hemoglobin (HbA1c) as a detection step. The prevalence of Hb variant in this southern French population was 0.71%, with the highest frequency for the beta-globin variants (n = 342/363; i.e., 94.2%), including the most common: S, C, E, and D in 200/342 (58.5%), 83/342 (24.3%), 29/342 (8.5%), and 11/342 (3.2%), respectively. Among patients with Hb variants, almost half (165/363; i.e., 45.4%) were born in the African continent with a predominance for Morocco (32/165; i.e., 19.3%) and Algeria (29/165; i.e., 17.5%).
UNASSIGNED: HbA1c assay is a useful tool to detect Hb variants. Hemoglobinopathies are a public health issue in the current French population which is a multiethnic society. Despite the monocentric nature of our
study, we note a high frequency of Hb variants in the south of France, which underlines the importance of screening for Hb variants in the whole population.