关于血液恶性肿瘤的生物学以及免疫系统在控制这些疾病中的作用的知识的增加导致了免疫疗法的开发和批准,这些免疫疗法产生了令人印象深刻的临床反应。因此,癌症免疫治疗协会(SITC)召集了一个由医生组成的血液恶性肿瘤癌症免疫治疗指南小组,护士,耐心的倡导者,并为多发性骨髓瘤患者免疫治疗的临床应用制定共识建议,淋巴瘤和急性白血病.这些建议是根据医学研究所的临床实践指南按照先前建立的流程制定的。在这样做的时候,我们对2004年至2014年的高影响力研究进行了系统的文献检索,并补充了小组确定的进一步文献.共识小组于2014年12月举行会议,目标是为血液系统恶性肿瘤患者的免疫治疗临床应用提供共识建议。在这次会议期间,使用共识小组投票和讨论对文献检索的支持证据的强度进行评分和审查.这些共识建议侧重于与患者选择相关的问题,毒性管理,临床终点,以及测序或疗法的组合。总的来说,免疫治疗正在迅速成为血液系统恶性肿瘤的有效治疗策略.提供了有关其临床应用的循证共识建议,并将随着该领域的发展而更新。
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval of immunotherapies that are resulting in impressive clinical responses. Therefore, the Society for Immunotherapy of Cancer (SITC) convened a hematologic malignancy Cancer Immunotherapy
Guidelines panel consisting of physicians, nurses, patient advocates, and patients to develop
consensus recommendations for the clinical application of immunotherapy for patients with multiple myeloma, lymphoma, and acute leukemia. These recommendations were developed following the previously established process based on the Institute of Medicine\'s clinical practice
guidelines. In doing so, a systematic literature search was performed for high-impact studies from 2004 to 2014 and was supplemented with further literature as identified by the panel. The
consensus panel met in December of 2014 with the goal to generate
consensus recommendations for the clinical use of immunotherapy in patients with hematologic malignancies. During this meeting, consensus panel voting along with discussion were used to rate and review the strength of the supporting evidence from the literature search. These consensus recommendations focus on issues related to patient selection, toxicity management, clinical endpoints, and the sequencing or combination of therapies. Overall, immunotherapy is rapidly emerging as an effective therapeutic strategy for the management of hematologic malignances. Evidence-based
consensus recommendations for its clinical application are provided and will be updated as the field evolves.