Head And Neck Neoplasms

头颈部肿瘤
  • 文章类型: Case Reports
    Protection of cranial nerves is one of the major challenges in the resection of paragangliomas of head and neck, especially in complex paragangliomas. We report a case of bilateral jugular tumor with unilateral carotid body tumor. Baroreflex failure syndrome(BFS) occurred after staged resection of bilateral lesions. There is still a lack of effective treatment for this complication. More prudent and reasonable treatment strategy is important to reduce the incidence of BFS.
    摘要:颅神经保护是头颈部副神经节瘤(Paragangliomas)切除术的主要挑战之一,特别是对于同时发生在双侧的复杂副神经节瘤病例。本文报道了1例双侧颈静脉球瘤合并单侧颈动脉体瘤的病例,在分期切除双侧病灶后发生了压力反射衰竭综合征。这种并发症尚缺乏有效的治疗手段,制定谨慎而合理的治疗策略是降低其发生率的关键。.
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  • 文章类型: Journal Article
    BACKGROUND: Cervical lipomas accompanied by neurovascular compression are extremely rare and require surgical treatment in case of appropriate symptoms. The preferable method is gross total resection, as otherwise they tend to recur. Invasive growth is not typical for lipomas. However, large tumors can involve adjacent nerves and vessels and significantly complicate resection.
    METHODS: We present a 57-year-old patient who underwent resection of giant soft tissue cervical lipoma invading neurovascular bundle and compressing the oropharynx and esophagus with dysphagia and positional asphyxia. The patient was followed-up for previous 5 years. Resection was necessary due to tumor enlargement with appropriate symptoms. Searching for literature data was performed in the Pubmed, Medline, EMBASE, Cochrane Library and eLibrary databases.
    CONCLUSIONS: Gross total resection of 7-cm tumor was accompanied by mobilization of hypoglossal and vagus nerves, common, external and internal carotid arteries and jugular vein with repositioning of the oropharynx and esophagus. There was mild Horner\'s syndrome in early postoperative period. The patient was discharged in 4 days after surgery with regression of complaints. We found only 5 reports describing giant cervical lipomas invading neurovascular bundle.
    CONCLUSIONS: Giant cervical lipomas are extremely rare, and total resection with preservation of critical structures is possible in a specialized hospital.
    Липомы, сопровождающиеся компрессией сосудисто-нервного пучка шеи, встречаются крайне редко и требуют хирургического лечения в случаях появления соответствующей симптоматики. Предпочтительным методом является радикальное удаление, так как в противном случае они склонны рецидивировать. Для липом не характерен инвазивный рост, однако, достигая больших размеров, они могут вовлекать в себя прилежащие нервные и сосудистые структуры, что значительно затрудняет радикальную хирургическую резекцию.
    UNASSIGNED: В статье представлено наблюдение пациента 57 лет, которому было произведено удаление гигантской липомы мягких тканей шеи, распространяющейся в сосудисто-нервный пучок и приводящей к компрессии ротоглотки, пищевода, дисфагии и позиционной асфиксии при повороте головы. Пациент наблюдался по поводу образования в течение 5 лет, в связи с увеличением образования в динамике и нарастанием жалоб было принято решение об его удалении. Произведен поиск литературы по ключевым словам в научных базах данных PubMed, Medline, EMBASE, Cochrane Library и eLibrary.
    UNASSIGNED: В ходе операции опухоль 7 см в диаметре была полностью удалена, из нее выделены и сохранены подъязычный, блуждающий нервы, общая, наружная и внутренняя сонные артерии и яремная вена, сдавленные ротоглотка и пищевод приняли нормальное положение. В раннем послеоперационном периоде отмечалось появление минимально выраженного синдрома Горнера, пациент был выписан из клиники на 4-е сутки после операции с регрессом жалоб. При поиске литературы было найдено лишь 5 работ, описывающих гигантские липомы шеи с вовлечением сосудисто-нервного пучка.
    UNASSIGNED: Гигантские липомы шеи встречаются крайне редко, а их радикальное удаление с сохранением критических структур возможно в условиях специализированного стационара.
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  • 文章类型: Journal Article
    机器人手术的广泛接受正在扩展到口腔手术。对微创技术的需求正在推动对机器人颈部手术的美容和肿瘤学益处的研究。这项研究使用倾向评分匹配来分析机器人辅助颈部淋巴结清扫术的临床过程和术后结果,以提高肿瘤疗效和手术安全性。在2020年5月至2024年4月之间,200名OSCC患者接受了手术,其中42名被排除在外。该队列包括158名患者,其中128人进行了单侧颈清扫术,其中30人进行了双侧颈清扫术。36例患者进行了机器人辅助颈淋巴结清扫术(RAND),而122例患者进行了常规经颈淋巴结清扫术(CTND)。数据分析包括几个因素,包括淋巴结取出和围手术期结果,1:1倾向得分匹配,以确保公平性。选择39个颈部标本中的每一个和36个患者。CTND组比RAND组大8岁,但在原发部位和临床分期方面相似。RAND组的手术时间比CTND组长55分钟,血流引流量多140cc,但是住院时间和重症监护病房的时间是一样的,并且取出的淋巴结数量相同。存活率在所有阶段也没有差异。这表明RAND在围手术期或肿瘤学结果方面绝不逊于CTND,并展示了机器人辅助手术的安全性,即使是需要皮瓣的患者或晚期患者。
    The widespread acceptance of robotic surgery is extending to oral procedures. The demand for minimally invasive techniques is driving research into the cosmetic and oncologic benefits of robotic neck surgery. This study used propensity score matching to analyze the clinical course and postoperative outcomes of robot-assisted neck dissections for oncologic efficacy and surgical safety. Between May 2020 and April 2024, 200 OSCC patients underwent surgery and 42 were excluded. The cohort included 158 patients, 128 of whom underwent unilateral neck dissection and 30 of whom underwent bilateral neck dissection. Robotic-assisted neck dissection (RAND) was performed in 36 patients while conventional transcervical neck dissection (CTND) was performed in 122 patients. Data analysis included several factors, including lymph node retrieval and perioperative outcomes, with 1:1 propensity score matching to ensure fairness. Each of the 39 neck specimens with 36 patients was selected. The CTND group was 8 years older overall than the RAND group, but otherwise similar in terms of primary site and clinical stage. The RAND group had a 55-min longer operative time and 140 cc more hemovac drainage than the CTND group, but the hospital stay and intensive care unit duration were the same, and the number of lymph nodes retrieved was the same. Survival rates also showed no difference across all stages. This shows that RAND is in no way inferior to CTND in terms of perioperative or oncologic outcomes, and demonstrates the safety of robot-assisted surgery, even in patients who require flaps or in patients with advanced stages.
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  • 文章类型: Journal Article
    背景:经典霍奇金淋巴瘤(CHL)的特征是淋巴网状系统的恶性细胞增殖,并且通常涉及淋巴结,脾,脾肝脏,和骨髓;它在头部和颈部区域很少见。
    方法:一名58岁的男性左腭扁桃体溃疡增大,导致吞咽困难。显微镜检查发现大量浸润,非典型淋巴样细胞分化簇30、分化簇15、PAX5和EB病毒阳性。补充测试最初排除了疾病的其他部位。结果导致诊断为在扁桃体中CHL的罕见发展,被上演为IIEB。在开始治疗之前,颈部出现结节病变,CHL作为IIB重新分类.患者采用阿霉素方案成功治疗,博来霉素,长春碱,还有达卡巴嗪.在对文献进行回顾之后,作者发现只有3例临床病例,成像,腭扁桃体原发性CHL的微观特征。
    结论:尽管是罕见的事件,CHL可能首先在结外部位发展,比如腭扁桃体.在这种情况下,牙医的作用对于疾病的早期诊断至关重要。需要对口咽部原发性扁桃体CHL的发展进行调查,因为该疾病的临床病程与结节病变不同。
    BACKGROUND: Classical Hodgkin lymphoma (CHL) is characterized by a proliferation of malignant cells of the lymphoreticular system and often involves lymph nodes, spleen, liver, and bone marrow; it is rare in the head and neck region.
    METHODS: A 58-year-old man had an enlargement with ulceration in the left palatine tonsil that was causing dysphagia. Microscopic examination revealed an infiltrate of large, atypical lymphoid cells positive for cluster of differentiation 30, cluster of differentiation 15, PAX5, and Epstein-Barr virus. Complementary tests initially ruled out other sites of the disease. The results led to diagnosis of a rare development of CHL in the palatine tonsil, which was staged as IIEB. Before therapy was initiated, nodal lesions developed in the neck and the CHL was restaged as IIB. The patient was treated successfully with a regimen of doxorubicin, bleomycin, vinblastine, and dacarbazine. After a review of the literature, the authors found only 3 cases with the clinical, imaging, and microscopic features of primary CHL of the palatine tonsil.
    CONCLUSIONS: Despite being a rare event, CHL may first develop in extranodal sites, such as the palatine tonsil. In this context, the role of the dentist is pivotal for early diagnosis of the disease. Investigations into the development of primary tonsillar CHL in the oropharynx are needed because the disease has a different clinical course than nodal lesions.
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  • 文章类型: Journal Article
    颈部肿块是初级保健服务的常见表现。在文献中对颈后肿块的病因研究甚少,因此仍然是患者和临床医生关注的问题。这通常会导致超声评估的紧急转诊。这项研究的作者试图从放射学的角度评估后颈肿块的病因,为了评估超声是否可以用作有用的辅助手段,而不是一线紧急调查.
    进行了回顾性病例系列研究,检查所有初级保健参考超声研究,以评估颈部后肿块,在埃塞克斯的一个机构演出,英国,在2012年2月2日至2022年11月8日期间超过10年。收集了以下数据:研究时的患者年龄,患者性,无论肿块是单发还是多发,由初级保健医生触诊和记录,肿块的大小最接近0.5厘米,如使用最长尺寸的超声记录,超声诊断和任何后续成像(不限于超声)。
    共对615名成年人进行了623次颈部超声检查。在623次扫描的总体放射学诊断中,555(89.09%)扫描为良性,63次(10.11%)扫描在超声检查中没有发现肿块,和3(0.48%)扫描显示恶性肿瘤。在剩下的2次(0.32%)扫描中,肿块被认为是不确定的。良性肿块最常见的病因是:正常淋巴结(n=263;42.21%),脂肪瘤(n=152;24.39%),良性真皮囊肿(n=105;16.85%)。3例恶性肿瘤均有颈前后肿块并存。
    鉴于我们研究中绝大多数的后颈肿块都是良性的,我们建议仅有单发或甚至多发后颈肿块的患者,无论大小,都可以进行常规检查,也可以根据其他临床检查特征进行确认.存在并存的前后颈部可触及的颈部肿块的患者,可以进行紧急或2周的等待放射学检查。
    UNASSIGNED: Neck lumps are a common presentation to primary care services. The aetiology of posterior neck lumps is poorly explored in the literature, and therefore remain a concern to patients and clinicians. This often results in an urgent referral for ultrasound assessment. The authors of this study sought to evaluate the aetiology of posterior neck lumps from a radiological perspective, to assess whether ultrasound can be used as a useful adjunct, rather than a first-line urgent investigation.
    UNASSIGNED: A retrospective case series was carried out, examining all primary care referred ultrasound studies for assessment of posterior neck lumps, performed at a single institution in Essex, United Kingdom, over a period of over 10 years dating between 2nd February 2012 to 8th November 2022. Data was collected on: patient age at the time of study, patient sex, whether the lump was single or multiple as palpated and documented by the primary care physician, size of the lump to the nearest 0.5 cm as documented on ultrasound using the longest dimension, sonographic diagnosis and any follow up imaging (not limited to ultrasound).
    UNASSIGNED: A total of 623 neck ultrasounds were performed on 615 adults. Of the overall radiological diagnoses made from the 623 scans, 555 (89.09%) scans were benign, 63 (10.11%) scans had no lump found on sonography, and 3 (0.48%) scans showed malignancy. In the remaining 2 (0.32%) scans, the lump was deemed indeterminate. The most common aetiologies for benign lumps were due to: normal lymph nodes (n = 263; 42.21%), lipomas (n = 152; 24.39%), and benign dermal cysts (n = 105; 16.85%). All 3 malignant cases had co-existing anterior and posterior neck lumps.
    UNASSIGNED: Given that the overwhelming majority of posterior neck lumps in our study had benign findings, we propose that patients with solitary or even multiple posterior neck lumps alone, regardless of size can either be investigated routinely or can be reassured depending on other clinical examination characteristics. Patients who have the presence of co-existing anterior and posterior neck palpable neck lumps justifies urgent or 2-week wait radiological investigation.
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  • 文章类型: Journal Article
    背景:肌内血管瘤(IMH)占普通人群中所有良性软组织肿瘤的0.8%或更少。由于它们不寻常的性质,尤其是头部和颈部,它们经常被误诊,不包括在鉴别诊断中。
    方法:本研究通过回顾性回顾科罗拉多州儿童医院病理科(CHCO)的电子健康记录和档案记录,描述了11例诊断为IMH的儿科患者的病例系列。
    结果:索引病例在颌下三角有独特的表现,其余十例为阑尾和胸腰椎。
    结论:此案例系列有助于获得有关IMH的稀疏科学文献,特别是与耳鼻喉科医师相关的头颈部表现。
    BACKGROUND: Intramuscular hemangiomas (IMH) account for 0.8 % or less of all benign soft tissue tumors in the general population. Due to their uncommon nature, especially in the head and neck, they are often misdiagnosed and not included in the differential diagnosis.
    METHODS: This study describes a case series of eleven pediatric patients with a diagnosis of IMH through a retrospective review of the electronic health records and archival records in the Department of Pathology at Children\'s Hospital of Colorado (CHCO).
    RESULTS: The index case had a unique presentation in the submandibular triangle, while the remaining ten cases are appendicular and thoracolumbar in nature.
    CONCLUSIONS: This case series contributes to the sparse scientific literature available regarding IMH, particularly in its head and neck presentation as relevant to otolaryngologists.
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  • 文章类型: Journal Article
    背景:T2N0声门鳞状细胞癌(SCC)通常对放疗(RT)反应良好;然而,实现本地控制仍然具有挑战性。在RT失败的情况下,全喉切除术可能是必要的。改善局部控制和喉部的保存直接提高了患者的生活质量。我们使用日本头颈部癌症登记处(JHNCR)进行的回顾性分析旨在比较RT和放化疗(CRT)对T2N0声门SCC患者的临床益处。
    方法:使用JHNCR(2011-2015)的数据,我们纳入了1,231例T2N0声门型SCC患者。其中,346人接受治愈性RT,425人接受治愈性CRT。CRT组进一步分为口腔CRT(OralCRT,N=120)和静脉CRT(DIVCRT,N=305)组。本研究评估了局部控制率(LCR),无进展生存期(PFS),总生存率(OS)。使用1:1倾向评分匹配分析来调整患者特征。
    结果:匹配后,105对RT与口服CRT相比,和224对比较RT和DIVCRT。变量在匹配的人群中平衡良好。在匹配的人群中,口服CRT组的5年LCR和PFS明显优于RT组(LCR,89.4%与80.6%,P=0.043;和PFS,85.5%与72.3%,分别为P=0.025),而DIVRT组的5年PFS明显优于RT组(80.1%vs.68.6%,P=0.026)。
    结论:在T2N0声门型SCC患者的RT中加入口服化疗时,观察到更好的局部和疾病控制的临床益处。因此,在RT中加入口服化疗剂治疗T2N0声门型SCC的意义需要进一步前瞻性研究.
    BACKGROUND: T2N0 glottic squamous cell carcinoma (SCC) typically responds well to radiotherapy (RT); however, achieving local control remains challenging. In cases of RT failure, total laryngectomy may be necessary. Improved local control and preservation of the larynx directly enhances patients\' quality of life. Our retrospective analysis using the Japan Head and Neck Cancer Registry (JHNCR) aimed to compare the clinical benefits of RT and chemoradiotherapy (CRT) in patients with T2N0 glottic SCC.
    METHODS: Using data from the JHNCR (2011-2015), we included 1,231 patients with T2N0 glottic SCC. Among them, 346 received curative RT and 425 underwent curative CRT. The CRT group was further divided into the oral CRT (Oral CRT, N=120) and intravenous CRT (DIV CRT, N=305) groups. This study assessed local control rate (LCR), progression-free survival (PFS), and overall survival (OS). A 1:1 propensity score-matching analysis was used to adjust for patient characteristics.
    RESULTS: After matching, 105 pairs compared RT with Oral CRT, and 224 pairs compared RT with DIV CRT. The variables were well-balanced in the matched populations. In the matched populations, the Oral CRT group had significantly better 5-year LCR and PFS than the RT group (LCR, 89.4 % vs. 80.6 %, P=0.043; and PFS, 85.5 % vs. 72.3 %, P=0.025, respectively), while the DIV RT group had significantly better 5-year PFS than the RT group (80.1 % vs. 68.6 %, P=0.026).
    CONCLUSIONS: The clinical benefits of better local and disease controls were observed when oral chemotherapy was added to RT in patients with T2N0 glottic SCC. Thus, the significance of adding oral chemotherapeutic agents to RT in the treatment of T2N0 glottic SCC requires further prospective investigation.
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  • 文章类型: Case Reports
    背景:囊性水瘤在成年期的表现非常罕见。成人囊性水瘤的罕见性在其诊断和治疗中引起了问题,很少有研究报道成人囊性水瘤。
    方法:在本研究中,我们报道了一例罕见的成人宫颈囊性水瘤。我们报告了一名20岁的伊朗男性(伊朗种族),诊断为右侧颈部囊性水瘤,并讨论了该表现,诊断,临床,放射学,和它的操作方面。
    结论:囊性湿度瘤在成人中是罕见的。他们通常无症状,很少复杂,可能会被误认为是颈部囊性肿块.这项研究表明,在我们的案例中,手术切除可能是一种安全有效的治疗囊性水瘤的方法,在手术过程中并发症的风险最小。
    BACKGROUND: Manifestation of cystic hygroma in adulthood is very rare. The rarity of cystic hygroma in adults has caused problems in its diagnosis and management and few studies have reported cystic hygroma in adults.
    METHODS: In this study, we reported a rare case with cervical cystic hygroma in adults. We report a 20-year-old Iranian male (Iranian ethnicity) with a diagnosis of right-side neck cystic hygroma and discuss the presentation, diagnosis, and clinical, radiological, and operative aspects of it.
    CONCLUSIONS: Cystic hygromas are a rare occurrence in adults. They are typically asymptomatic, rarely complicated, and can be mistaken for a cystic neck mass. This study showed that in our case, surgical resection may be a safe and effective treatment for cystic hygroma, with minimal risk of complications during the procedure.
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  • 文章类型: Journal Article
    背景与目的75岁以上的患者占头颈部肿瘤人群的20%,这是临床文献中相对代表性不足的患者队列。据我们所知,没有研究评估75岁以上患者喉切除术的结果,这促使我们提出这个独特的系列。方法我们回顾了大学学院医院的科室记录,伦敦在10年的时间里,并确定了18例75岁以上的患者接受了全喉切除术治疗鳞状细胞癌。我们评估了人口统计,临床,以及每位患者的组织病理学特征和结果。结果队列年龄75~90岁,平均年龄79.8岁.所有患者的Charlson合并症指数(CCI)评分均为3分或更高(由于年龄),2例患者的平均得分为4.7分,最高得分为8分。住院时间差异很大,从20天到149天,平均46天。我们确定了14例2017年9月之前接受喉切除术的患者,其中5年生存率为21.4%。所有患者的3年生存率为22.2%。在双变量分析中,高龄手术与住院时间增加和并发症发生率增加呈正相关,尽管这些结果没有统计学意义(p<0.05)。结论我们的研究强调了年龄和合并症对术后结果的影响的重要性,并阐明了人口老龄化所面临的独特挑战。必须仔细考虑选择适当的病人,临床医生必须为老年人护理提供稳健和量身定制的方法。
    Background and objective Patients over the age of 75 years make up 20% of the head and neck cancer population, which is a relatively under-represented patient cohort in clinical literature. To our knowledge, there are no studies evaluating the outcomes of laryngectomy in patients aged over 75 years, which prompted us to present this unique series. Methods We reviewed departmental records at the University College Hospital, London over a 10-year period, and identified a total of 18 patients over the age of 75 years who underwent total laryngectomy for squamous cell carcinoma. We evaluated the demographic, clinical, and histopathologic features and outcomes for each patient. Results The age of the cohort ranged from 75 to 90 years, with a mean age of 79.8 years. All patients had a Charlson Comorbidity Index (CCI) score of 3 or more (due to age), with a mean of 4.7, and a maximum score of 8 for two patients. Length of inpatient stay varied significantly, ranging from 20 to 149 days, with a mean of 46 days. We identified 14 patients who underwent laryngectomy prior to September 2017, in whom the five-year survival was 21.4%. The three-year survival rate for all patients was 22.2%. In bivariate analysis, advanced age at surgery positively correlated with increased length of hospital admission and increased incidence of complications, although these results were not statistically significant (p<0.05). Conclusions Our study highlights the significance of the impact of age and comorbidities on postoperative outcomes and sheds light on the unique challenges faced by an ageing population. Careful consideration must be made in terms of appropriate patient selection, and clinicians must offer a robust and tailored approach to elderly care.
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