背景：长链非编码RNA（lncRNA）在调节与细胞增殖有关的基因表达中具有重要作用，生存,迁移和基因组稳定性。lncRNAs表达失调与癌症发生有关，进展和转移。
目的：探索，绘制并总结了从调查lncRNAs在口腔/舌鳞状细胞癌中差异表达的临床研究中获得的证据范围。
方法：PubMed，Scopus和WebofScience被用作搜索引擎。临床,全长,包括英语语言研究。PRISMA-ScR方案用于评估和呈现结果。本范围综述总结了lncRNAs的差异表达与肿瘤的存在以及包括生存在内的临床病理特征之间的关系。
结果：在一项以上的研究中已经探索了几乎一半的研究转录本，但并不总是有一致的结果。还将收集的数据与调查口腔上皮发育不良的有限研究进行了比较。数据不容易比较，首先，因为定义差异表达的方法不同，其次，因为只有有限数量的研究进行了多变量分析，以确定与差异表达lncRNAs相关的临床病理特征。
结论：需要标准方法和更适当的数据分析，以便从未来的研究中获得可靠的结果。
BACKGROUND: Long non-coding RNAs (lncRNAs) have important roles in regulating gene expression pertaining to cell proliferation, survival, migration and genomic stability. Dysregulated expression of lncRNAs is implicated in cancer initiation, progression and metastasis.
OBJECTIVE: To explore, map and summarize the extent of evidence from clinical studies investigating the differential expression of lncRNAs in oral/tongue squamous cell carcinoma.
METHODS: PubMed, Scopus and Web of Science were used as search engines. Clinical, full-length, English language studies were included. PRISMA-ScR protocol was used to evaluate and present results. The present scoping
review summarizes relationships of the differential expression of lncRNAs with the presence of tumour and with clinicopathological features including survival.
RESULTS: Almost half of the investigated transcripts have been explored in more than one study, yet not always with consistent results. The collected data were also compared to the limited studies investigating oral epithelial dysplasia. Data are not easily comparable, first because of different methods used to define what differential expression is, and second because only a limited number of studies performed multivariate analyses to identify clinicopathological features associated with the differentially expressed lncRNAs.
CONCLUSIONS: Standard methods and more appropriate data analyses are needed in order to achieve reliable results from future studies.
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