■我们研究的目的是评估主观疾病负担参数(SVR和OP)以及客观疾病负担参数(BCVA和ODI)作为埃及BD葡萄膜炎患者HRQoL的预测因子。
■本横断面研究从风湿科招募了96名BD葡萄膜炎患者,开罗大学医院HRQoL使用RAND-36项目健康调查1.0进行评估,主观视觉评分(SVR)以6点Likert量表进行测量。眼痛(OP)在数字评定量表上进行评分。使用BD损伤指数的眼域计算眼损伤指数(ODI)。进行线性回归以确定HRQoL指标的预测因子。
■SVR预测活力(β=0.15,p=0.004),情绪幸福感(EW)(β=0.13,p=0.005),一般健康状况(β=0.18,p=0.012)和精神成分汇总(β=0.22,p=0.002)。OP预测社会功能(β=-3.18p<0.001),一般健康状况(β=-1.55,p=0.004),身体成分汇总(β=-2.00,p=0.007)和心理成分汇总(β=-1.53,p=0.005)。BCVA预测身体功能(β=31.1,p=0.02)和情绪健康(β=7.94,p=0.01)。ODI无法预测任何HRQoL指标。ODI是根据葡萄膜炎持续时间和严重程度调整的法定失明的独立预测因子。法律失明患者的HRQoL指标比视力更好的患者差。
■在BD葡萄膜炎患者中,主观疾病负担参数对HRQoL指标的信息比客观参数更多。需要进行纵向研究以阐明ODI作为BD葡萄膜炎的结果指标的实用性。
■在Behcet的葡萄膜炎患者中,健康相关的生活质量与视觉结果有关,眼痛,和主观视觉评级。眼部损害是法定失明的独立预测因子,调整葡萄膜炎的持续时间和严重程度。
UNASSIGNED: The aim of our
study is to assess subjective disease burden parameters (SVR and OP) as well as objective ones (BCVA and ODI) as predictors of HRQoL in Egyptian patients with BD uveitis.
UNASSIGNED: Ninety-six patients with BD uveitis were recruited in this cross-sectional
study from the Rheumatology Department, Cairo University Hospital. HRQoL was assessed using RAND-36 item health survey 1.0, subjective visual rating (SVR) was measured on a 6-point Likert scale. Ocular pain (OP) was rated on a numeric rating scale. The Ocular Damage Index (ODI) was calculated using the ocular domain of the BD damage index. Linear regression was performed to determine predictors of
HRQoL metrics.
UNASSIGNED: SVR predicted Vitality (β = 0.15, p = 0.004), Emotional Well-being (EW) (β = 0.13, p = 0.005), General Health (β = 0.18, p = 0.012) and Mental Component Summary (β = 0.22, p = 0.002). OP predicted Social Function (β = -3.18 p < 0.001), General Health (β = -1.55, p = 0.004), Physical Component Summary (β = -2.00, p = 0.007) and Mental Component Summary (β = -1.53, p = 0.005). BCVA predicted Physical Function (β = 31.1, p = 0.02) and Emotional Well-being (β = 7.94, p = 0.01). ODI failed to predict any
HRQoL metrics. ODI was independent predictor of legal blindness adjusted for uveitis duration and severity. Legally blind patients had worse
HRQoL metrics than patients with better vision.
UNASSIGNED: In BD uveitis patients, subjective disease burden parameters were more informative about HRQoL metrics than objective ones. Longitudinal studies are needed to elucidate the utility of ODI as an outcome measure in BD uveitis.
UNASSIGNED: In Behcet\'s uveitis patients, health-related quality of life was related to visual outcome, ocular pain, and subjective visual rating. Ocular damage was an independent predictor of legal blindness, adjusted for uveitis duration and severity.