■研究以站立代替坐着对临床试验中测试的心血管危险因素的影响。
■我们搜索了从成立到2019年8月28日的数据库,以研究以站立代替坐姿对空腹血糖的影响。空腹胰岛素,和血脂水平;血压;身体脂肪量;体重;健康成年人的腰围。平均值±SD值的差异用于汇集数据并计算平均差异和CI。
■搜索找到3507个摘要。9项临床试验(8项随机和1项非随机)877名(64.4%[n=565]名女性)参与者符合所有纳入标准。平均±SD年龄为45.34±5.41岁;平均随访时间为3.81个月,干预组和对照组站立时间的平均差异为每天1.33小时.与对照组相比,干预组的随访空腹血糖和体脂质量值略低于基线记录(-2.53;95%CI,-4.27至-0.79mg/dL;和-0.75;95%CI,-0.91至-0.59kg)。空腹胰岛素水平的分析,脂质水平,血压,体重,和腰围没有显着差异。
■用站立代替坐着可以导致空腹血糖水平和身体脂肪量的非常小但具有统计学意义的下降,而对血脂水平没有显着影响,血压,体重,和腰围。用站立代替坐着可以用作辅助干预措施,以减少心血管危险因素的负担,但不能用作身体活动的替代方法,以减少久坐时间。
UNASSIGNED: To investigate the effect of replacing sitting with standing on cardiovascular risk factors tested in clinical trials.
UNASSIGNED: We searched databases from inception up to August 28, 2019, for studies examining the effect of replacing sitting with standing on fasting blood glucose, fasting insulin, and lipid levels; blood pressure; body fat mass; weight; and waist circumference in healthy adults. Differences in mean ± SD values were used for pooling the data and calculating the mean differences and CIs.
UNASSIGNED: The search found 3507 abstracts. Nine clinical trials (8 randomized and 1 nonrandomized) with 877 (64.4% [n=565] women) participants met all inclusion criteria. The mean ± SD age was 45.34±5.41 years; mean follow-up was 3.81 months, and mean difference in standing time between the intervention and control groups was 1.33 hours per day. The follow-up fasting blood glucose and body fat mass values were slightly but significantly lower than baseline records in the intervention groups compared with control groups (-2.53; 95% CI, -4.27 to -0.79 mg/dL; and -0.75; 95% CI, -0.91 to -0.59 kg). The analysis for fasting insulin levels, lipid levels, blood pressure, weight, and waist circumference revealed no significant differences.
UNASSIGNED: Replacing sitting with standing can result in very small but statistically significant decreases in fasting blood glucose levels and body fat mass with no significant effect on lipid levels, blood pressure, weight, and waist circumference. Replacing sitting with standing can be used as an adjunctive intervention to decrease the burden of cardiovascular risk factors but cannot be used as an alternative to physical activity to decrease sedentary time.