Glaucoma, Open-Angle

青光眼,打开角度
  • 文章类型: Journal Article
    本文是第四个芬兰当前诊断护理指南的英文翻译,原发性开角型青光眼的治疗和随访,正常眼压青光眼和假性剥脱性青光眼。本指南基于系统的文献综述和专家意见,并考虑到芬兰的地理和运营医疗保健环境。
    This article is an English translation of the 4th Finnish Current Care Guideline for diagnostics, treatment and follow-up of primary open-angle glaucoma, normal-tension glaucoma and pseudoexfoliative glaucoma. This guideline is based on systematic literature reviews and expert opinions with Finland\'s geographical and operational healthcare environment in mind.
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  • 文章类型: Journal Article
    背景:为了评估青光眼嫌疑人临床实践指南的质量,并评估他们如何定义“青光眼嫌疑人”的一致性,以及他们对此类个体开始治疗的建议。
    方法:本研究包括所有自我认定为“指南”的文件,并为青光眼嫌疑人的临床护理提供建议。使用评估研究和评估指南(AGREE)II工具评估合格指南的质量。
    结果:从综合搜索中检索到的1196条记录和手动包含的两条记录中,20个临床实践指南被认为是合格的。根据使用AGREEII工具的评估,16(80%)指南有≤2个领域,得分>66%。总的来说,得分最低的领域是适用性,编辑独立性和利益相关者参与。关于“青光眼可疑者”或“原发性开角型青光眼[POAG]可疑者”的定义,指南之间的一致性相对较差,以及在这些人群中开始治疗的建议和标准。对于“原发性闭角嫌疑犯”的治疗开始的定义和建议达成了更好的共识。
    结论:目前大多数国际青光眼疑似病例临床指南的方法学质量仍有很大的提高空间。临床医生在使用此类指南告知他们对青光眼嫌疑人的护理时,应考虑这一发现。POAG疑似病例的定义和开始治疗的建议存在很大差异,这突显了当前准确预测这些个体青光眼发展和治疗有效性的证据中的重要差距。
    BACKGROUND: To appraise the quality of clinical practice guidelines for glaucoma suspects, and to assess their consistency for how a \'glaucoma suspect\' is defined and their recommendations for treatment initiation for such individuals.
    METHODS: This study included all documents that self-identified as a \'guideline\' and provided recommendation(s) for the clinical care of glaucoma suspects. The quality of eligible guidelines was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument.
    RESULTS: From 1196 records retrieved from comprehensive searches and two records manually included, 20 clinical practice guidelines were deemed eligible. Based on an appraisal using the AGREE II instrument, 16 (80%) guidelines had ≤2 domains with scores >66%. Overall, the lowest scoring domains were for applicability, editorial independence and stakeholder involvement. There was relatively poor agreement across the guidelines for what defines a \'glaucoma suspect\' or \'primary open angle glaucoma [POAG] suspect\', as well as the recommendations and criteria for treatment initiation in these populations. There was better agreement for the definition and recommendations for treatment initiation for \'primary angle closure suspects\'.
    CONCLUSIONS: There is substantial room to improve the methodological quality of most current international clinical guidelines for glaucoma suspects. Clinicians should consider this finding when using such guidelines to inform their care of glaucoma suspects. Substantial variation in the definition of a POAG suspect and recommendations for treatment initiation underscores important gaps in the current evidence for the accurate prediction of glaucoma development and treatment effectiveness in these individuals.
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  • 文章类型: Editorial
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  • 文章类型: Journal Article
    青光眼是印度第二大失明原因。尽管在诊断和治疗青光眼方面取得了进展,缺乏印度特有的青光眼临床指南.眼科医生经常参考欧洲青光眼学会(EGS)和亚太青光眼学会(APGS)指南。召集了一组青光眼专家来审查最近发布的EGS指南(第五版)和APGS指南,并探讨它们与印度背景的相关性。这篇评论提供了EGS和APGS指南的显着特征及其在印度方案中的实用性。青光眼的诊断应基于视力和屈光不正,裂隙灯检查,房角镜检查,眼压测定,视野(VF)测试,视神经乳头的临床评估,视网膜神经纤维层(RNFL),和黄斑。眼内压目标必须针对眼睛进行个性化处理,并在每次访问时进行修改。前列腺素类似物是最有效的药物,被推荐为开角型青光眼(OAG)的首选。在白内障和原发性闭角型青光眼(PACG)患者中,建议单独超声乳化或联合超声乳化和青光眼手术。推荐使用抗纤维化药物增强的小梁切除术作为OAG的初始手术治疗。年龄<50岁的高危人群应考虑激光周边虹膜切开术和手术结合药物治疗。在Phakic和PACG患者中,建议单独超声乳化或联合超声乳化和青光眼手术。视敏度,VF测试,视盘和RNFL的临床评估,和眼压测量法强烈建议监测青光眼进展。
    Glaucoma is the second leading cause of blindness in India. Despite advances in diagnosing and managing glaucoma, there is a lack of India-specific clinical guidelines on glaucoma. Ophthalmologists often refer to the European Glaucoma Society (EGS) and Asia-Pacific Glaucoma Society (APGS) guidelines. A group of glaucoma experts was convened to review the recently released EGS guideline (fifth edition) and the APGS guideline and explore their relevance to the Indian context. This review provides the salient features of EGS and APGS guidelines and their utility in Indian scenario. Glaucoma diagnosis should be based on visual acuity and refractive errors, slit-lamp examination, gonioscopy, tonometry, visual field (VF) testing, and clinical assessment of optic nerve head, retinal nerve fiber layer (RNFL), and macula. The intraocular pressure target must be individualized to the eye and revised at every visit. Prostaglandin analogues are the most effective medications and are recommended as the first choice in open-angle glaucoma (OAG). In patients with cataract and primary angle-closure glaucoma (PACG), phacoemulsification alone or combined phacoemulsification and glaucoma surgery are recommended. Trabeculectomy augmented with antifibrotic agents is recommended as the initial surgical treatment for OAG. Laser peripheral iridotomy and surgery in combination with medical treatment should be considered in high-risk individuals aged <50 years. In patients with phakic and PACG, phacoemulsification alone or combined phacoemulsification and glaucoma surgery are recommended. Visual acuity, VF testing, clinical assessment of the optic disc and RNFL, and tonometry are strongly recommended for monitoring glaucoma progression.
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  • 文章类型: Journal Article
    唯一的时间是现在。每个“现在”都是独一无二的。负责人问自己,“我现在如何表现得很好?”每个人的答案都不同,因为正如每一种情况都是独一无二的,每个人都与其他人不同。但是肯定有一些算法可以帮助我们找到正确的答案。不幸的是,不,因为没有正确的答案。在这种情况下,只有一个答案是我们当时可以得出的结论。没有书面指南可以适当地适用于每一个独特的情况。不幸的是,我们的医生被一个谬论所欺骗:“对鹅有好处的东西对公鹅有好处。“用医学术语来说,“正常的发现是好的,异常的发现是不好的。“这太简单了,而且经常是错误的。好的临床医生知道护理必须个性化才能达到最佳。所谓的正常发现给出了粗略的指导,有时适用于群体,但对个人来说往往是错误的。考虑眼内压(IOP)。15mmHg的正常眼压对一些人有利,对另一些人不利,30mmHg的异常IOP对某些人有利,对另一些人不利。我们被标准分布曲线神圣性的神话所轰炸,以至于很难独立和具体地思考。此外,不幸的是,医生倾向于为病人做决定,通常基于对特定患者不相关或不重要的规范数据。我们这样做并不奇怪,当我们想要帮助时,所以我们默认了看似简单的东西,安全(非思考)的方式,我们不必对结果负责。总得有人来决定,否则我们将生活在一个无政府状态的世界。也是如此。因为我们中没有人知道我们需要知道如何采取适当的行动,我们向所谓的“专家”寻求建议。“对于我们来说,要照顾好人们,我们必须考虑别人的建议。所以我们期待专家,正如我们应该。然而,专家有时是对的,有时是错的。记得VonGraefe在1860年推荐手术虹膜切除术治疗所有青光眼,艾略特建议肩膀之间的芥末石膏治疗青光眼,Becker基于色调学结果的治疗,我们报告说,青光眼穿透性环流疗法100%成功,Lichter建议不要进行激光小梁成形术,很多人认为Cypass很棒,研究人员在高级青光眼干预研究中指出,通常在12mmHg左右的IOP优于通常在20mmHg左右的IOP。都错了.这些指南的作者做得很好,是提供一个通用框架,眼科医生可以在该框架上悬挂证据,以便能够评估证据的有效性和重要性。他们一丝不苟地为所有眼科医生提供了宝贵的服务,他们中没有人个人有充分的时间或技能。在他们自己的实践中,作者考虑有效信息是否与被考虑的特定人相关。考虑相关性的过程至关重要,总是。相关性是基于特定的独特患者,独特的医生和独特的情况。作者在这方面可以提供的唯一指南是提醒我们所有人在所有情况下考虑与所有患者的相关性,从病人的角度来看。比对眼科医生的服务更重要的是,周到地使用这些指南对患者的好处。我们需要,还,记住诊断是通用的,在每个诊断中都有差异。例如,初级开角的诊断意味着什么?尽管经过了最周到的治疗,一些受影响的人会迅速失明,而另一些人即使没有治疗也会保持视力。Chandler综合征的诊断是什么意思?在某些情况下,手术效果很好,and,在其他方面,差。所以一个人从不指导诊断和治疗,而是在人身上,目标是那个人的健康。以前的欧洲青光眼协会指南在国际上使用。很高兴EGS再次提供更新,有用的信息。准则是一个切实可行的,鼓舞人心的贡献。
    The only time is now. Every \"now\" is unique. Responsible persons ask themselves, \"How can I act well now?\" The answers will differ for every person, because just as every situation is unique, so is every person different from every other person. But surely there must be some algorithm that will assist us in coming to the right answer. Unfortunately, no, for there is no right answer. There is only an answer that is as appropriate as we can conclude at that moment in that situation. No written guidelines can apply appropriately to every unique situation.Unfortunately we physicians have been suckled on a fallacy: \"What\'s good for the goose is good for the gander.\" Phrased in medical terms, \"normal findings are good, and abnormal findings are bad.\" This is too simple, and often wrong.Good clinicians know that care must be personalized for it to be optimal. So-called normal findings give rough guidance, sometimes applicable to groups, but frequently wrong for individuals. Consider intraocular pressure (IOP). A normal IOP of 15 mmHg good for some and bad for others, and an abnormal IOP of 30 mmHg is good for some and bad for others. We are so bombarded by the myth of the sanctity of the standard distribution curve that it is hard to think independently and specifically. Also, unfortunately, doctors are prone to decide for patients, often on the basis of normative data that is not relevant or important for the particular patient. That we do this is not surprising, as we want to help, and so we default to what seems to be the easy, safe (non-thinking) way, in which we do not have to hold ourselves accountable for the outcome.Somebody HAS to decide, or else we would be living in an anarchical world. Also true. And because none of us knows as much as we need to know to act appropriately, we seek advice from so-called \"experts.\"For us to care for people well it is essential that we consider what others recommend. So we look to experts, as we should. However, experts are sometimes right and sometimes wrong. Remember that von Graefe in 1860 recommended surgical iridectomy for all glaucoma, Elliot recommended mustard plaster between the shoulders for glaucoma, Becker based treatment on tonographic findings, Weve reported 100% success with penetrating cyclodiathermy in glaucoma, Lichter advised against laser trabeculoplasty, many thought Cypass was great, and the investigators in the Advanced Glaucoma Intervention Study indicated that an IOP usually around 12 mmHg was better than one usually around 20 mmHg. All wrong. What the authors of these guidelines have done excellently, is to provide a general framework on which ophthalmologists can hang pieces of evidence, so as to be able to evaluate the validity and the importance of that evidence. In doing this meticulously they have provided a valuable service to all ophthalmologists, none of whom individually have either the time or the skill to be fully informed. In their own practices the authors consider whether valid information is relevant for the particular person being considered. That process of considering relevance is essential, always. And relevance is based on the particular unique patient, unique doctor and unique situation. The only guideline the authors can provide in this regard is to remind us all to consider relevance with all patients in all situations, and from the patient\'s perspective. Even more important than the service to ophthalmologists is the benefit to patients that will result from thoughtful use of these guidelines.We need, also, to remember that diagnoses are generic, and that within every diagnosis there are differences. For example what does a diagnosis of primary open angle mean? Some of those affected will rapidly go blind despite the most thoughtful treatment and others will keep their sight even without treatment. What does a diagnosis of Chandler\'s Syndrome mean? In some, surgery works well, and, in others, poorly. So one never directs diagnosis and treatment at a condition, but rather at the person, the objective being the wellness of that person.The previous European Glaucoma Society Guidelines are used internationally. It is good that the EGS is again providing updated, useful information.The Guidelines are a practical, inspirational contribution.
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  • 文章类型: Journal Article
    Purpose: To evaluate the prescribing habits of glaucoma specialists and of general ophthalmologists, and reveal the conformance with European Glaucoma Society (EGS) guidelines in the medical treatment of primary open-angle glaucoma (POAG) and ocular hypertension (OHT). Methods: Patients receiving medical treatment for POAG/OHT in the glaucoma clinic comprised the \"naive group.\" Patients having a diagnosis and a treatment for POAG/OHT initiated in another center before presentation comprised the second group and were named as \"treatment initiated elsewhere\" (TIEW). All patients were retrospectively evaluated from the patients\' charts. The outcome measures included the percentage of eyes treated with monotherapy, the molecule groups preferred, and the change in prescription trends over the years in both groups. Results: Seventy-two subjects were included in the naive group and 135 subjects in TIEW group. The rate of monotherapy was 76% and 36% in both groups, respectively. The molecule number was significantly higher in the TIEW group compared with naive group (1.98 ± 0.89 vs. 1.28 ± 0.56, P < 0.001). Until 2003, beta blockers, and in the 2003-2008 period, prostaglandin analogs (PGAs) were the mostly prescribed drugs in glaucoma clinic. From 2009, the rate of PGAs declined, with PGAs being replaced by combination drugs and alfa-2 agonists. Conclusions: Overtreatment rate was high among patients receiving a diagnosis and a treatment by general ophthalmologists, whereas glaucoma specialists were found to conform with EGS guidelines. A shift toward polypharmacy was observed from 2000 to 2017. The common guidelines to evaluate and treat glaucoma need to be adopted by the general ophthalmologists in their real-life practice.
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  • 文章类型: Journal Article
    Glaucoma is a group of progressive optic neuropathies featuring retinal ganglion cell and axonal degeneration, which typically manifest as sunken atrophy of optic papilla and characteristic visual field defect. Genetic factors play an important role in the pathogenesis of glaucoma. This guideline mainly focuses on single gene mutation-related glaucoma by summarizing the pathogenic genes, disease diagnosis and clinical consultation of primary congenital glaucoma (PCG) and primary open-angle glaucoma (POAG), with an aim to regulate their molecular diagnosis, genetic counseling and treatment.
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  • 文章类型: Journal Article
    目的:确定青光眼专家认为最重要和最实用的一组青光眼手术结果指标。
    方法:一百零二位青光眼专家(英国和欧洲青光眼学会(UKEGS)的57位成员和欧洲青光眼学会(EGS)的45位成员)参加了在线Delphi练习。使用RAND/UCLA适当性方法分析每一轮的数据并生成分歧指数。
    结果:参与者就13个基线数据点和12个结果达成一致,这些数据点被认为是重要且实用的。对于眼内压(IOP),IOP从基线的百分比降低(术后前最后三个IOP读数)和低于指定目标的降低被认为是重要的。对于视野,全局视野指数的变化,例如,MD,和通过线性回归评估的进展发展被认为是重要的。从安全的角度来看,导致最小分辨率角度加倍的任何视觉损失,5dB或更多的视野损失或高级视野损失的发展(HodappParrishAnderson阶段4)被认为是重要的。强调了常规使用患者报告结果测量(PROM)的重要性。共识建议青光眼治疗的结果应在1年、5年和10年报告。
    结论:关于报告青光眼手术结果和结果测量间隔的最小数据集存在广泛共识。
    OBJECTIVE: To identify the key set of glaucoma surgery outcome measures considered most important and practical to collect by glaucoma specialists.
    METHODS: One hundred two glaucoma specialists (57 members of the UK and Eire Glaucoma Society (UKEGS) and 45 members of the European Glaucoma society (EGS)) took part in an Online Delphi exercise. The RAND/UCLA appropriateness method was used analyse data from each round and generate a disagreement index.
    RESULTS: Participants agreed on 13 baseline data points and 12 outcomes that were considered important and practical to collect. For intraocular pressure (IOP) percentage reduction in IOP from baseline (last three IOP readings pre-op) and reduction below a specified target were considered important. For visual fields, change in a global visual field index, e.g. MD, and development of progression as assessed by linear regression were considered important. From a safety perspective, any visual loss resulting in a doubling of the minimal angle of resolution, loss of 5 dB or more of visual field or development of advanced field loss (Hodapp Parrish Anderson Stage 4) was considered important. The importance of routinely using patient reported outcome measures (PROMs) was highlighted. Consensus suggested that outcomes of glaucoma treatments should be reported at 1, 5 and 10 years.
    CONCLUSIONS: There was broad consensus on a minimum dataset for reporting the outcomes of glaucoma surgery and outcome measurement intervals.
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