UNASSIGNED: Glanders is a rare disease that has been eradicated in many countries but may be difficult to diagnose due to its nonspecific symptoms. This disease, which can be highly fatal if left untreated, is caused by a bacterium called Burkholderia mallei. Humans can get the disease through contact with infected animals, such as horses. Over time, various treatment strategies have been proposed for this disease, and attempts haveeven been made to develop a vaccine, but thus far, no effective vaccine has been developed to prevent it.
UNASSIGNED: In this article, we describeacase of Glanders disease in KamkarArabnia Hospital in Qom, Iran. The patient was a 22-year-old man with headache, fever, chills, diarrhea, and vomiting of blood, and was admitted to the infectious ward in isolation.
UNASSIGNED: The lack of definitive diagnostic symptoms and the rarity of this disease make it difficult to diagnose, and one should be careful in dealing with its symptoms. Also, paying attention to the patient\'s medical history and travel history to endemic areas, can lead to timely diagnosis and treatment.

Glanders is a rare zoonotic disease caused by Burkholderia mallei. Humans can be infected by B. mallei, which causes cutaneous lymphadenitis and pneumonia, leading to sepsis and death in severe cases.
We report a case of a 60-year-old male who was diagnosed with glanders. The patient who had a history of diabetes presented with cough, expectoration, and fever. Computed tomography (CT) imaging showed B. mallei infection in the right upper lobe of the lung with mediastinal lymph node involvement and the lingual segment of the left lung. Moreover, the posterior basal segment of the lower lobe of both lungs had inflammation. Subsequently, B. mallei infection was confirmed by lymph node biopsy and bronchoalveolar lavage multiplex PCR-based targeted gene sequencing. After meropenem treatment, the patient was discharged, and CT imaging showed reduced absorption of pulmonary inflammatory lesions.
Glanders is a rare disease that can cause skin infection, lymphadenitis, and pneumonia, and in severe cases, it can be life-threatening. The diagnosis of this disease mainly relies on microbiological culture and pathological biopsy. Diagnosis is also facilitated by multiplex PCRbased targeted gene sequencing. Glanders is treated with cephalosporins, carbapenems, and other sensitive antibiotics.

Glanders is a relatively unknown zoonotic disease caused by Burkholderia mallei. This bacterium affect solipeds and humans, and can be used as a biological warfare. Glanders is characterized as an occupational disease. We report the case of an 11-year-old boy who was presented to an emergency department with chest pain and dyspnea. He evolved into septic shock, pneumonia, and multiple abscesses. B. mallei was found in the exudate culture. Human infection is rare and difficult to confirm. The knowledge on glanders is important for differential diagnosis from other serious illnesses causing pneumonia and multiple abscesses.

Within 2 months of acquiring glanders, a patient developed 8-, 16-, and 4-fold increases, respectively, in specific IgA, IgG, and IgM serological titers against Burkholderia mallei. Within 14 months of infection, the titers decreased to the baseline. Serum from this patient was also highly reactive against Burkholderia pseudomallei whole cells. Burkholderia mallei whole cells did not react with sera from patients with other diseases. Therefore, an assay using a B. mallei cellular diagnostic antigen may be useful for the serodiagnosis of glanders.

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