背景:格兰德斯是一种罕见的由伯克霍尔德氏菌引起的人畜共患疾病。人类可以被B.Mallei感染,导致皮肤淋巴结炎和肺炎,导致严重的败血症和死亡。
方法:我们报告一例60岁男性,诊断为腺体。有糖尿病病史的患者出现咳嗽,咳痰,和发烧。计算机断层扫描(CT)成像显示右肺上叶有纵隔淋巴结受累和左肺舌段的B.mallei感染。此外,双肺下叶后基底段有炎症。随后,通过淋巴结活检和基于支气管肺泡灌洗的多重PCR的靶向基因测序证实了B.mallei感染。美罗培南治疗后,病人出院了,CT成像显示肺部炎性病变吸收减少。
结论:格兰德斯是一种可引起皮肤感染的罕见疾病,淋巴结炎,还有肺炎,在严重的情况下,可能会危及生命.本病的诊断主要依靠微生物培养和病理活检。通过基于多重PCR的靶向基因测序也促进诊断。格兰德斯用头孢菌素治疗,碳青霉烯类,和其他敏感抗生素。
Glanders is a rare zoonotic disease caused by Burkholderia mallei. Humans can be infected by B. mallei, which causes cutaneous lymphadenitis and pneumonia, leading to sepsis and death in severe cases.
We report a
case of a 60-year-old male who was diagnosed with
glanders. The patient who had a history of diabetes presented with cough, expectoration, and fever. Computed tomography (CT) imaging showed B. mallei infection in the right upper lobe of the lung with mediastinal lymph node involvement and the lingual segment of the left lung. Moreover, the posterior basal segment of the lower lobe of both lungs had inflammation. Subsequently, B. mallei infection was confirmed by lymph node biopsy and bronchoalveolar lavage multiplex PCR-based targeted gene sequencing. After meropenem treatment, the patient was discharged, and CT imaging showed reduced absorption of pulmonary inflammatory lesions.
Glanders is a rare disease that can cause skin infection, lymphadenitis, and pneumonia, and in severe cases, it can be life-threatening. The diagnosis of this disease mainly relies on microbiological culture and pathological biopsy. Diagnosis is also facilitated by multiplex PCRbased targeted gene sequencing.
Glanders is treated with cephalosporins, carbapenems, and other sensitive antibiotics.