神经系统疾病变得越来越普遍，人们正在大力寻找可以帮助治疗它们的分子。几个天然成分，尤其是那些来自类黄酮的，已经显示出有希望的结果。银杏素是第一个已知的双类黄酮，从银杏中分离出的一种类黄酮二聚体。稍后，它的出现是在20多种不同的植物物种中发现的，其中大多数都以其在传统医学中的用途而闻名。本文总结了银杏素的神经保护潜能数据。有证据表明可以防止缺血性中风引起的神经元损伤，神经肿瘤，阿尔茨海默病（AD），和帕金森病（PD）。在缺血性中风中的有益作用已在动物研究中得到证实,其中在中风发作之前或之后注射银杏素显示出对神经元损伤的保护作用。AD保护是迄今为止研究最多的。可能的机制包括抑制活性氧，抑制β-分泌酶，抑制Aβ原纤维形成，炎症的改善，和抗菌活性。在动物研究中，银杏素也显示出对缓解PD症状的积极作用。大多数可用数据来自体外或体内动物研究，银杏素显示出有希望的结果，应进行进一步的临床研究。
Neurological disorders are becoming more common, and there is an intense search for molecules that can help treat them. Several natural components, especially those from the flavonoid group, have shown promising results.
Ginkgetin is the first known biflavonoid, a flavonoid dimer isolated from ginkgo (Ginkgo biloba L.). Later, its occurrence was discovered in more than 20 different plant species, most of which are known for their use in traditional medicine. Herein we have summarized the data on the neuroprotective potential of
ginkgetin. There is evidence of protection against neuronal damage caused by ischemic strokes, neurotumors, Alzheimer\'s disease (AD), and Parkinson\'s disease (PD). Beneficial effects in ischemic strokes have been demonstrated in animal studies in which injection of
ginkgetin before or after onset of the stoke showed protection from neuronal damage. AD protection has been the most studied to date. Possible mechanisms include inhibition of reactive oxygen species, inhibition of β-secretase, inhibition of Aβ fibril formation, amelioration of inflammation, and antimicrobial activity.
Ginkgetin has also shown positive effects on the relief of PD symptoms in animal studies. Most of the available data are from in vitro or in vivo animal studies, where
ginkgetin showed promising results, and further clinical studies should be conducted.
