背景:固定假牙(FDP)可以影响炎性细胞因子的产生,从而导致牙周组织的损伤。对以下两个目标进行了系统评价和荟萃分析:(1)确定金属-陶瓷(M/C)和全瓷(A-Cs)假体牙齿的龈沟液(GCF)中存在的不同炎性细胞因子的患病率和功能,(2)分析并比较M/C和A-Cs假体牙齿GCF中炎性细胞因子的水平。
方法:该方案遵循PRISMA和Cochrane指南,并在OSF:10.17605/OSF中注册。IO/RBHJU。在PubMed/MEDLINE数据库中进行了数字搜索,科克伦图书馆,牙科和口腔科学来源,Scopus,WebofScience,ScienceDirect,和谷歌学者,7月15日,2000年至3月1日,2024.使用JBI工具进行横断面和纵向研究评估研究质量。使用随机效应模型进行荟萃分析,以评估具有M/C和A-CFDP的牙齿GCF中IL-1β的浓度。
结果:搜索策略共提供了8,172篇文章,其中14项调查符合纳入标准。研究的患者总数为468,其中53%为女性,其余(47%)为男性。患者的年龄从19岁到73岁不等,平均年龄±标准差(SD)为38,5±12,8岁。共研究了843个固定假牙,其中407(48,27%)为M/C假体,410(48,63%)为A-C假体。我们发现IL-1β的水平,IL-1α,PGE2,NKA,CGRP,与使用A-Cs假体的牙齿相比,使用M/C假体的牙齿和CX3CL1增加。Meta分析显示,与使用A-Cs假体的牙齿相比,使用M/C假体的牙齿的GCF中IL-1β水平没有显着差异(SMD=13.89pg/ml(CI=-14.29-42.08),p=>0.05)。
结论:与使用A-Cs假体的牙齿相比,在使用M/C假体的牙齿的GCF中发现了炎性细胞因子水平升高的趋势。
BACKGROUND: Fixed dental prostheses (FDP) can affect the production of inflammatory cytokines causing damage to periodontal tissues. A systematic review and meta-analysis was carried out with the following two objectives: (1) to determine the prevalence and function of the different inflammatory cytokines present in gingival crevicular fluid (GCF) of teeth with metal-ceramic (M/C) and all-ceramic (A-Cs) prostheses, and (2) to analyze and compare the levels of inflammatory cytokines in GCF of teeth with M/C and A-Cs prostheses.
METHODS: The protocol followed PRISMA and Cochrane guidelines and was registered in the OSF:10.17605/OSF.IO/RBHJU. A digital search was conducted in the databases PubMed/MEDLINE, Cochrane Library, Dentistry & Oral Sciences Source, Scopus, Web of Science, ScienceDirect, and Google Scholar, from July 15th, 2000 to March 1st, 2024. Study quality was assessed using the JBI tool for cross-sectional and longitudinal studies. A meta-analysis was performed using a random-effects model to evaluate the concentration of IL-1β in GCF of teeth with FDP of M/C and A-Cs.
RESULTS: The search strategy provided a total of 8,172 articles, of which 14 investigations met the inclusion criteria. The total number of patients studied was 468 of whom 53% were women and the rest (47%) were men. The ages of the patients ranged from 19 to 73 years, with a mean age ± standard deviation (SD) of 38,5 ± 12,8 years. A total of 843 fixed dental prostheses were studied, of which 407 (48,27%) were M/C prostheses and 410 (48,63%) were A-Cs prostheses. We found that the levels of IL-1β, IL-1α, PGE2, NKA, CGRP, and CX3CL1 were increased in teeth with M/C prostheses compared to teeth with A-Cs prostheses. Meta-analysis revealed that there are no significant differences between IL-1β levels in GCF in teeth with M/C prostheses compared to teeth with A-Cs prostheses (SMD = 13.89 pg/ml (CI = -14.29-42.08), p = > 0.05).
CONCLUSIONS: A trend toward increased levels of inflammatory cytokines was found in GCF of teeth with M/C prostheses compared to teeth with A-Cs prostheses.