尽管人们普遍认识到髋部骨折患者的髋部BMD降低,有和没有髋部骨折的受试者在诸如皮质体积和厚度等几何参数上的差异并不为人所知。
这项横断面研究包括了5162名社区居住的老年妇女进行了髋关节CT扫描,其中236人患有急性髋部骨折。326名年龄匹配的无髋部骨折妇女作为对照。使用MIAF-股骨软件测量髋部骨折患者的完整对侧股骨和对照组的左股骨。总髋关节(TH)的积分和皮质体积(Vols),股骨头(FH),股骨颈(FN),对转子(TR)和转子间(IT)进行分析。在FH和FN中,体积进一步细分为上前(SA)和后(SP)以及下前(IA)和后(IP)象限。测定上面列出的所有感兴趣的子体积(VOI)的皮质厚度(CortThick)。
对照组和骨折组的平均年龄分别为71.7和72.0岁,分别。除TRVol外,骨折患者的所有VOI的CortThick和Vol均显着降低。在骨折患者中,除象限SA的皮质体积外,所有象限中FN的皮质厚度和体积均显着降低(p=0.635)。髋部骨折患者在调整年龄前后的整体FN体积和横截面积(CSA)较小,身高和体重。关于髋部骨折的辨别,整个股骨近端的皮质体积比皮质厚度差。Cort/TrabMass比值(RCTM),测量骨骼的内部分布,在区分髋部骨折风险方面优于皮质厚度。对于包含THCortThick的模型,获得了最高的曲线下面积(AUC)值0.805,FHVol,THRCTM和FNCSA。
股骨近端骨折和未骨折的女性在总体积和皮质体积以及皮质厚度方面存在显著差异。几何变量的组合对髋部骨折风险的辨别能力与aBMD相似。
Although it is widely recognized that hip BMD is reduced in patients with hip fracture, the differences in geometrical parameters such as cortical volume and thickness between subjects with and without hip fracture are less well known.
Five hundred and sixty two community-dwelling elderly women with hip CT scans were included in this cross-sectional study, of whom 236 had an acute hip fracture. 326 age matched women without hip fracture served as controls. MIAF-Femur software was used for the measurement of the intact contralateral femur in patients with hip fracture and the left femur of the controls. Integral and cortical volumes (Vols) of the total hip (TH), femoral head (FH), femoral neck (FN), trochanter (TR) and intertrochanter (IT) were analyzed. In the FH and FN the volumes were further subdivided into superior anterior (SA) and posterior (SP) as well as inferior anterior (IA) and posterior (IP) quadrants. Cortical thickness (CortThick) was determined for all sub volumes of interest (VOIs) listed above.
The average age of the control and fracture groups was 71.7 and 72.0 years, respectively. The fracture patients had significantly lower CortThick and Vol of all VOIs except for TRVol. In the fracture patients, cortical thickness and volume at the FN were significantly lower in all quadrants except for cortical volume of quadrant SA (p= 0.635). Hip fracture patients had smaller integral FN volume and cross-sectional area (CSA) before and after adjustment of age, height and weight. With respect to hip fracture discrimination, cortical volume performed poorer than cortical thickness across the whole proximal femur. The ratio of Cort/TrabMass (RCTM), a measure of the internal distribution of bone, performed better than cortical thickness in discriminating hip fracture risk. The highest area under curve (AUC) value of 0.805 was obtained for the model that included THCortThick, FHVol, THRCTM and FNCSA.
There were substantial differences in total and cortical volume as well as cortical thickness between fractured and unfractured women across the proximal femur. A combination of geometric variables resulted in similar discrimination power for hip fracture risk as aBMD.