背景:关于儿童硬化性苔藓的研究有限,and,到目前为止,没有研究比较男孩和女孩的硬化性苔藓的病程。我们试图检查所有关于患有硬化性苔藓的男孩和女孩的出版物,并评估和比较流行病学,症状和体征,遗传背景,危险因素,治疗,和预后。
方法:在Embase中进行了系统搜索,Medline,科克伦,和WebofScience数据库。纳入标准是有关0-18岁儿童的信息,以及临床或组织学诊断为硬化性苔藓。回顾了1985年至2021年的文献。
结果:检索到1780篇文章,其中90篇文章有资格列入。男孩和女孩在许多方面表现相似;尽管如此,治疗和随访方法不同。
结论:尽管临床方法通常不同,男孩和女孩的硬化性苔藓表现出许多相似之处。需要更多的研究,特别是在后续行动中,更好地了解硬化性苔藓的病程,并建立先进的儿童管理计划。
BACKGROUND: Studies concerning pediatric lichen sclerosus are limited, and, to date, there have been no studies comparing the course of lichen sclerosus in boys and girls. We sought to examine all publications on boys and girls with lichen sclerosus and assess and compare epidemiology, symptoms and signs, genetic background, risk factors, treatment, and prognosis.
METHODS: A systematic search was performed in the Embase, Medline, Cochrane, and Web of Science databases. Inclusion criteria were information on children ages 0-18 years and a clinical or histologic diagnosis of lichen sclerosus. Literature from 1985 to 2021 was reviewed.
RESULTS: A total of 1780 articles were retrieved from the search, of which 90 articles were eligible for inclusion. Boys and girls present similarly on many aspects; nonetheless, treatment and follow-up are approached differently.
CONCLUSIONS: Though the clinical approach is often different, lichen sclerosus in boys and girls demonstrates many similarities. More research is needed, especially on follow-up, to gain a better understanding of the course of lichen sclerosus and establish an advanced management plan for children.