目的:大麻素在各种医疗疾病的自我管理中广泛使用。然而,不良反应已被报道使用,特别是与成人和老年患者的胃肠道系统有关。这些范围从恶心,呕吐,腹胀,或腹痛。对先前报道的成人人群中大麻引起的胃肠道症状的系统综述从文献中提供了相关数据的分析,以增强对该主题的认识和认识。
方法:PubMed,OvidMEDLINE,CochraneCentral,从EMBASE和GoogleScholar数据库中搜索了从成立到2023年3月发表的相关研究。
结果:搜索产生了598个结果,其中13项被认为是相关的,并接受了进一步审查。其中包括两项系统审查,一项回顾性队列研究,一次回顾性图表审查,两项横断面研究,一项调查,和六个病例报告。在相关的地方应用了用于偏倚分析的Cochrane风险工具。选择进行分析的研究中的总人数为79,779人。在13项纳入的研究中,有12项报告了医疗和/或娱乐性大麻使用者经历的某种胃肠道症状,包括恶心,呕吐,腹泻,腹痛,成人肠套叠。
结论:潜在的限制包括样本量小,研究方法的变化,各种各样的研究设计,以及关于特定人群如老年用户的数据有限。有必要进行进一步的研究,以增加与这一新兴的重要主题有关的当前证据,填补广泛的知识空白,并为医疗保健专业人员提供基于证据的指南,确保安全的处方实践和提供优质的护理。
Cannabinoid usage is widespread in the self-management of various medical ailments. However, adverse effects have been reported with use, especially pertaining to the gastrointestinal system in adults and aged patients. These range from nausea, vomiting, bloating, or abdominal pain. This systematic
review of previously reported cannabis-induced gastrointestinal symptoms in the adult population from the literature provides an analysis of relevant data to enhance knowledge and awareness of this topic.
PubMed, Ovid MEDLINE, Cochrane Central, EMBASE, and Google Scholar databases were searched for relevant studies published from inception to March 2023.
The search yielded 598 results, of which 13 were deemed relevant and underwent further
review. These included two systematic reviews, one retrospective cohort study, one retrospective chart
review, two cross-sectional studies, one survey, and six case reports. The Cochrane Risk Tool for bias analysis was applied where relevant. The total number of people in the studies selected for analysis was 79, 779. Twelve out of the thirteen included studies reported some type of gastrointestinal tract symptoms experienced in medical and/or recreational cannabis users ranging from nausea, vomiting, diarrhoea, abdominal pain to adult intussusception.
Potential limitations include small sample sizes, variation in research methodologies, varied studied designs, and limited availability of data on specific populations such as geriatric users. Further research is warranted to add to current evidence pertaining to this emerging topic of significance, fill the broad knowledge gaps and contribute to evidence-based guidelines for healthcare professionals, ensuring safe prescribing practices and provision of quality care.