背景:塞内西奥的地上部分是布赫。-火腿.(菊科)在中医治疗各种疾病方面有着悠久的历史,比如细菌性腹泻,肠炎,结膜炎,和呼吸道感染。
方法:通过分析次要来源,完成了对Senecioscandens的书目调查,包括中药植物经典,互联网(谷歌学者和百度学者),和全球接受的科学数据库(Pubmed,Scopus,WebofScience,SciFinder,和CNKI)。仔细研究了这些来源,以获取有关千里光在中药中使用的现有信息,植物化学,药理学,和毒理学。
结果:千里光是一种具有攀援木本茎的药用植物。植物化学研究表明存在许多有价值的化合物,如类黄酮,生物碱,酚酸,萜烯,挥发油,类胡萝卜素,和微量元素。其中,PA是特征性的成分,adonifoline是Senecioscanens的指标成分之一。现代药理学研究表明,从千里光中分离出的提取物和化合物具有广泛的药理活性,包括消炎药,抗菌,抗钩端螺旋体病,保肝,抗感染性疾病,抗氧化剂,抗病毒,抗肿瘤,镇痛药,诱变,和毒理学活动。
结论:植物化学和药理研究表明,植物提取物具有各种药理活性,可归因于各种黄酮类化合物的存在,酚酸,和生物碱。需要开发用于PA的定性和定量方法的较新技术,以获得更好的准确性和灵敏度。由于这种药用植物中存在的PA的毒性,不同国家和地区对塞内西奥丑闻的法律规定各不相同。在中国,2010年《中国药典》对Senecioscanens的PAs毒性分级标准没有很好的定义,西方国家对PAs也没有严格的统一要求。我们建议应根据一组标准重新评估SenecioScandens的使用,其中包括风险-收益分析和毒性作用的严重程度,临床和临床前数据,以确保安全使用,同时继续满足获取药用植物的需求。
BACKGROUND: The aerial parts of Senecio scandens Buch.-Ham. (family Asteraceae) have a long history in traditional Chinese medicine as a treatment for various ailments, such as bacterial diarrhea, enteritis, conjunctivitis, and respiratory tract infections.
METHODS: A bibliographic investigation of Senecio scandens was accomplished by analyzing secondary sources, including the Chinese Medicinal plantal Classics, the Internet (Google Scholar and Baidu Scholar), and scientific databases accepted worldwide (Pubmed, Scopus, Web of Science, SciFinder, and CNKI). These sources were scrutinized for available information about the uses of Senecio scandens in traditional Chinese medicine, phytochemistry, pharmacology, and toxicology.
RESULTS: Senecio scandens is a medicinal plant with a climbing woody stem. Phytochemical studies have shown the presence of numerous valuable compounds, such as flavonoids, alkaloids, phenolic acids, terpenes, volatile oils, carotenoids, and trace elements. Among them, PAs are the characteristic constituents, adonifoline is one of the index ingredients of Senecio scandens. Studies in modern pharmacology have demonstrated that extracts and compounds isolated from Senecio scandens show a wide spectrum of pharmacological activities, including anti-inflammatory, antimicrobial, anti-leptospirosis, hepatoprotective, anti-infusorial, antioxidant, antiviral, antitumoral, analgesic, mutagenic, and toxicological activities.
CONCLUSIONS: Phytochemical and pharmacological studies have demonstrated that the extracts of the plant possess various pharmacological activities that can be attributed to the presence of various flavonoids, phenolic acids, and alkaloids. Newer technologies for qualitative and quantitative methods of PAs need to be developed to obtain better accuracy and sensitivity. Due to the toxicity of PAs present in this medicinal plant, the regulations on PAs of Senecio scandens were varied among different countries and regions. In China, the PAs toxicity of Senecio scandens ranking criteria is not well defined in the Chinese Pharmacopoeia 2010, and there is no strict uniform requirement on the PAs in western countries. We propose that the use of Senecio scandens should be reevaluated based on a set of criteria, which includes risk-benefit analysis and severity of the toxic effects, clinical and preclinical data to ensure safe use while continuing to satisfy the need for access to the medicinal plant.