The environmental conditions of a lake are influenced by its type and various environmental forces such as water temperature, nutrients content, and longitude and latitude to which it is exposed. Due to population growth and development limits, former mining lakes are being converted to more lucrative land uses like those of recreational zones, agriculture, and livestock. The fungus Ganoderma lucidum has the potential to be utilised as a substitute or to perform synergistic bacteria-coupled functions in efficient contaminated lake water treatment. The purpose of this paper is to evaluate the water quality and water quality index (WQI) of an ex-mining lake named Main Lake in the Paya Indah Wetland, Selangor. Furthermore, the current work simulates the use of a Malaysian fungus in decolourising the contaminated ex-mining lake by the BioDeF system in a 300 mL jar inoculated with 10% (v/v) of pre-grown Ganoderma lucidum pellets for 48 h. According to the results, the lake water is low in pH (5.49 ± 0.1 on average), of a highly intense dark brownish colour (average reading of 874.67 ± 3.7 TCU), and high in iron (Fe) content (3.2422 ± 0.2533 mg/L). The water quality index of the lake was between 54.59 and 57.44, with an average value of 56.45; thus, the water was categorized as Class III, i.e., under-polluted water, according to the Malaysian Department of Environment Water Quality Index (DOE-WQI, DOE 2020). The batch bioreactor BioDeF system significantly reduced more than 90% of the water\'s colour. The utilization of Ganoderma lucidum as an adsorbent material offers a variety of advantages, as it is easily available and cultivated, and it is not toxic.

As many prior case reports have shown, unregulated supplements and alcohol are both known to cause varying degrees of hepatotoxicity. We present a case of a 47-year-old male who presented to the hospital with headache and abdominal pain after consuming Reishi Mushroom (Ganoderma lingzhi) powder and alcohol. The patient was found to have acute hepatitis with significant transaminitis, which was managed conservatively with N-acetylcysteine and IV fluids. Two-week follow-up labs demonstrated complete resolution of the patient\'s symptoms and laboratory abnormalities. Despite the growing popularity of mushroom-based supplements, limited research has been done on the systemic effects that can manifest with co-ingestion of other substances such as alcohol.

The 5-year survival rate of non-small-cell lung cancer (NSCLC) is still low (<21%) despite recent improvements. Since conventional therapies have a lot of side effects, combined therapy is strongly recommended. Here, we report a patient with advanced NSCLC who received combined therapy, including ceritinib, photobiomodulation (PBM), ACGL (Antrodia cinnamomea (A. cinnamomea), and Ganoderma lucidum (G. lucidum)). Based on combined therapy, suitable doses of A. cinnamomea, G. lucidum, and PBM are important for tumor inhibition. This case report presents clinical evidence on the efficacy of combined therapy in advanced NSCLC patients, including computed tomography (CT) scan, magnetic resonance imaging (MRI), carcinoembryonic antigen (CEA), and blood tests. The effective inhibition of human lung adenocarcinoma cells is demonstrated. Our case highlights important considerations for PBM and ACGL applications in NSCLC patients, the side effects of ceritinib, and long-term health maintenance.

Parkinson\'s disease (PD) is a prevalent neurodegenerative disease for which only symptomatic treatments, mainly focused on motor symptoms. In contrast, conventional pharmacological treatments do not address cognitive impairment and emotional dysfunction. Together with potential treatment side effects, these can cause distress, lower the quality of life, and increase motor impairment in patients. Preclinical research suggests that the Traditional Chinese Medicine Ganoderma lucidum (\"Reishi\") can alleviate symptoms in neurological disorders like PD. However, no clinical research to date has addressed this. An (unmedicated) patient, 50 years of age and diagnosed with PD for 5 years, approached the author as he decided to initiate self-treatment with Reishi, lasting 3 months. He wanted to evaluate the effects and decide to continue self-treatment or not. He agreed to be followed during this period, using questionnaires asking him about his (non-)motor symptoms. The most notable finding was the increase in Mindfulness, 3 months after self-treatment started. The motor symptoms stayed stable, there were no extreme changes in quality of life, and emotion regulation seemed to deteriorate over time while slightly improving at the 3-month assessment. While the findings do not allow firm conclusions seen the nature (N = 1) of this study, the small positive changes in some facets of affective behavior and the patient\'s experience, combined with the evidence from preclinical research, warrant clinical studies in this patient population.