精神障碍与包括抑郁症在内的几种精神疾病密切相关,双相情感障碍,精神分裂症,饮食失调,和自杀。有许多生物学条件和途径定义了这些复杂的疾病。例如,饮食失调是复杂的心理健康状况,需要遗传学家的干预,精神病医生,和医学专家来缓解他们的症状。应首先识别具有自杀意念的患者,然后由类似的专家团队进行监测。遗传学和表观遗传学都可以揭示饮食失调和自杀,因为它们是此类研究的主要核心。在本研究中,已经对GPCR家族的两个特定成员进行了分析,以得出关于其在精神障碍中的功能和实施的结论.具体来说,已经对肾上腺素受体α2b(ADRA2B)和5-羟色胺受体1A(HTR1A)进行了进化和结构研究.这两种受体都被分类在GPCRs的生物胺受体亚簇中,并且在许多研究中都与精神疾病和营养不良状况有关。这项研究的主要目标是研究在该家族信号通路中起重要作用的生物胺受体中的保守基序,通过更新的进化分析以及这些信息与HTR1A和ADRA2B结构特征的相关性。此外,ADRA2B的结构比较,HTR1A,和其他与精神障碍相关的GPCRs成员进行。
Mental disorders are strongly connected with several psychiatric conditions including depression, bipolar disorder, schizophrenia, eating disorder, and suicides. There are many biological conditions and pathways that define these complicated illnesses. For example, eating disorders are complex mental health conditions that require the intervention of geneticists, psychiatrists, and medical experts in order to alleviate their symptoms. A patient with suicidal ideation should first be identified and consequently monitored by a similar team of specialists. Both genetics and epigenetics can shed light on eating disorders and suicides as they are found in the main core of such investigations. In the present
study, an analysis has been performed on two specific members of the GPCR family toward drawing conclusions regarding their functionality and implementation in mental disorders. Specifically, evolutionary and structural studies on the adrenoceptor alpha 2b (ADRA2B) and the 5-hydroxytryptamine receptor 1A (HTR1A) have been carried out. Both receptors are classified in the biogenic amine receptors sub-cluster of the
GPCRs and have been connected in many studies with mental diseases and malnutrition conditions. The major goal of this
study is the investigation of conserved motifs among biogenic amine receptors that play an important role in this family signaling pathway, through an updated evolutionary analysis and the correlation of this information with the structural features of the HTR1A and ADRA2B. Furthermore, the structural comparison of ADRA2B, HTR1A, and other members of
GPCRs related to mental disorders is performed.