The meta-analysis was conducted to investigate the impact of gamma-glutamyl carboxylase (
GGCX) on maintenance warfarin dose. 8 studies were included, focusing on the impact of
GGCX single nucleotide polymorphisms (SNPs) on mean daily warfarin dose (MDWD).
GGCX (rs699664; AA versus GG, GA versus GG, A versus GG) and
GGCX (rs12714145; GA versus GG, AA versus GG, A versus GG) showed no significant differences on mean daily warfarin dose (MDWD). This meta-analysis was the first to report the relationship between
GGCX SNPs and MDWD in Chinese populations. No evidence could be found in the relationship between SNPs of
GGCX (rs699664 and rs12714145) and maintenance warfarin dose.