背景:脉冲染料激光(PDL)在炎症性皮肤病治疗中的地位尚不清楚。缺乏基于证据的建议。
目的:我们试图系统地回顾所有关于PDL治疗炎症性皮肤病的文献,并提出建议。
方法:我们在PubMed数据库中搜索了1992年1月至2011年8月之间的出版物。获得了所有报告PDL治疗炎症性皮肤病的研究,并确定了证据水平。
结果:文献检索显示有52篇文章可纳入本研究。用PDL治疗的炎症性皮肤病包括:牛皮癣,寻常痤疮,红斑狼疮,面部肉芽肿,结节病,湿疹性病变,丘疹脓疱酒渣鼻,扁平苔藓硬化,环状肉芽肿,Jessner淋巴细胞浸润皮肤,和网状红斑粘液病。描述并评估了PDL激光治疗这些炎症性皮肤病的疗效。
结论:大多数结论并非基于随机对照试验。
结论:PDL治疗可被推荐为局部斑块状银屑病和寻常痤疮的有效和安全的治疗方法(推荐B级)。对于所有其他描述的炎症性皮肤病,PDL似乎很有希望,尽管推荐水平没有超过C级
BACKGROUND: The position of the pulsed dye laser (PDL) in the treatment of inflammatory skin diseases is still unclear. Evidence-based recommendations are lacking.
OBJECTIVE: We sought to systematically
review all available literature concerning PDL treatment for inflammatory skin diseases and to propose a recommendation.
METHODS: We searched for publications dated between January 1992 and August 2011 in the database PubMed. All studies reporting on PDL treatment for an inflammatory skin disease were obtained and a level of evidence was determined.
RESULTS: Literature search revealed 52 articles that could be included in this study. The inflammatory skin diseases treated with PDL consisted of: psoriasis, acne vulgaris, lupus erythematodes, granuloma faciale, sarcoidosis, eczematous lesions, papulopustular rosacea, lichen sclerosis, granuloma annulare, Jessner lymphocytic infiltration of the skin, and reticular erythematous mucinosis. The efficacy of PDL laser treatment for these inflammatory skin diseases was described and evaluated.
CONCLUSIONS: Most conclusions formulated are not based on randomized controlled trials.
CONCLUSIONS: PDL treatment can be recommended as an effective and safe treatment for localized plaque psoriasis and acne vulgaris (recommendation grade B). For all other described inflammatory skin diseases, PDL seems to be promising, although the level of recommendation did not exceed level C.