■这项工作回顾了有关特发性全厚度黄斑裂孔(FTMHs)自发闭合的文献。
■通过OvidMEDLINE对自发性特发性FTMH关闭患者的文献进行了综述,EMBASE,和PubMed至2020年7月16日。共纳入66篇已确定的文章中的27篇。
■共有68只眼自发闭合。在患者中,62.7%为女性,平均年龄为67.5岁。视敏度从Snellen20/78提高到闭合后的20/33。平均孔径为176.8μm;最大孔径为350μm。大多数是根据Gass的第2阶段,而根据国际玻璃体牵引研究组(IVTS)的分期,尺寸较小。最近文献中的主要分类系统是IVTS分期。光学相干断层扫描观察到的平均闭合时间为4.5个月。
■关于审查,报告的所有特发性FTMH的自发闭合率范围为3%至15%,并且没有人口统计学子群更有可能封闭。≤250µm的孔的闭合率(22.2%)高于>250至400µm(13.3%)和≥400µm(0%)的孔。闭合与良好的视觉结果相关,和视网膜桥接通过神经胶质细胞可能是关键的关闭。这些决定是基于有限的数字;需要前瞻性研究来进一步确定比率,机制,和特点。IVTS分期提供了可靠的报告,并了解了手术前是否可以观察到FTMH。
UNASSIGNED: This work reviews the literature regarding spontaneous closure of idiopathic full-thickness macular holes (FTMHs).
UNASSIGNED: Literature on patients with spontaneous idiopathic FTMH closure was reviewed via Ovid MEDLINE, EMBASE, and PubMed through July 16, 2020. A total of 27 of 66 identified articles were included.
UNASSIGNED: A total of 68 eyes had spontaneous closure. Of the patients, 62.7% were women and the average age was 67.5 years. Visual acuity improved from Snellen 20/78 to 20/33 post closure. The average hole diameter was 176.8 μm; the largest was 350 μm. Most were stage 2 according to Gass and of small size according to International Vitreomacular Traction Study Group (IVTS) staging. The predominant classification system in recent literature is IVTS staging. The average optical coherence tomography-observed closure time was 4.5 months.
UNASSIGNED: On
review, reported spontaneous closure rates of all idiopathic FTMH range from 3% to 15%, and no demographic subgroups are more likely to have closure. Holes ≤250 µm have higher closure rates (22.2%) than those in the range of >250 to 400 µm (13.3%) and ≥400 µm (0%). Closure is associated with favorable visual outcomes, and retinal bridging via glial cells is likely critical to closure. These determinations were based on limited numbers; prospective studies are needed to further ascertain rate, mechanism, and characteristics. IVTS staging provides reliable reporting and insight into whether FTMH can be observed before surgery.