目的:使用Flash葡萄糖监测(FGM)系统1年检查1型糖尿病(T1D)的血糖控制。
方法:这项前瞻性研究使用了187名T1D患者(14-40岁),他们通过FGM自我测试了他们的血糖水平。收集连续血糖监测(CGM)指标,即葡萄糖变异性(GV)(%),平均时间范围(TIR),超限时间(TAR),低于范围的时间(TBR),以及3,6和12个月时低血糖事件的平均持续时间.
结果:第6位,第9个月和第12个月,对于GV的值,%intarget,TAR和%>250mg/dL,与3个月相比,没有发现显着变化(p>0.05)。然而,从基线的显著变化是明显的平均葡萄糖水平的值在第3(p=0.028),第9个月(p=0.048)和第12个月(p=0.022)。将3个月时的平均葡萄糖值与6、9和12个月时的平均葡萄糖值进行比较,无明显变化(p>0.05)。当与基线值比较时,3个月时的低葡萄糖事件(p=0.028),6个月(p=0.048),9个月(p=0.022)和12个月(p=0.038)显示显着变化。然而,低于70毫克/分升的百分比(除非12个月时的值,p=0.046),没有观察到显著的变化。与基线值相比,HbA1c在3、6、9和12个月内显着下降。
结论:当患者从传统的手指穿刺方法切换到FGM系统时,CGM指标显着改善。并且在整个研究期间观察到效果。
OBJECTIVE: Examine the glycemic control on Type 1 Diabetes (T1D) wearing the Flash Glucose Monitoring (FGM) system for a one-year period of time.
METHODS: This prospective
study done using 187 patients with T1D (14-40yrs) who self-tested their glucose levels by FGM. Continuous glucose monitoring (CGM) metrics were gathered i.e., Glucose Variability (GV) (%), mean Time in Range (TIR), Time Above Range (TAR), Time Below Range (TBR), and average duration of hypoglycemic events at the 3, 6, and 12 month time periods.
RESULTS: At 6th, 9th and 12th months, for values of GV, % in target, TAR and %>250 mg/dL, no significant changes (p > 0.05) were noted compared to 3 months. However, significant changes from the baseline were evident for the values of the mean glucose level at the 3rd (p = 0.028), 9th (p = 0.048) and 12th months (p = 0.022). When the mean glucose value at 3 months was compared to the same at 6, 9, and 12 month period, no significant changes (p > 0.05) were seen. When compared with baseline values, low glucose events at 3 months (p = 0.028), 6 months (p = 0.048), 9 months (p = 0.022) and 12 months (p = 0.038) showed significant changes. However, the percentage below 70 mg/dL (barring the value at 12 months, p = 0.046), no significant changes were observed. The HbA1c revealed significant drop in 3, 6, 9 and 12 months compared to baseline values.
CONCLUSIONS: Significant improvement was noted in CGM metrics when patients switched from conventional finger pricking method over to FGM system, and the effect was observed during the entire
study period.