背景:实体器官移植最严重的副作用之一是移植后淋巴增生性疾病(PTLD)。人类免疫缺陷病毒感染(HIV)的人,一种与艾滋病毒相当的免疫抑制疾病,当他们的外周血含有高水平的免疫球蛋白κ和λ游离轻链(FLC)时,患淋巴瘤的机会更高。
方法:本系统综述的目的是监测PTLD患者的相关B淋巴瘤细胞。为了找到2000年1月1日至2022年1月9日之间发表的相关研究,两名独立研究人员进行了搜索(MT,AJ).使用MEDLINE通过PubMed对英语出版物进行了文献检索,EMBASETM通过Ovid,Cochrane图书馆,和旅行。除了Magiran和SID,我们搜索了KoreaMed和LILACS以获取其他语言发表的文献.sFLC或PTLD,移植,或电泳是搜索策略中使用的术语。
结果:共选择了174项研究。在分析了它们与所需标准的对应关系后,对五项研究进行了最后审查。该手稿提出了关于sFLC在PTLD中的临床适用性的潜在益处的最新发现。虽然初步结果似乎很有希望,唯一一致的结果是在移植后的头两年内预测早期发作的PTLD,可用于诊断病情的生物标志物。
结论:因此,已经通过使用sFLC预测了PTLD。迄今为止,已经出现了相互矛盾的结果。未来的研究可能包括评估移植受者sFLC的数量及其质量。除了PTLD和移植后的并发症,sFLC可以提供对其他疾病的洞察。为了确认sFLC的有效性,需要更多的研究。
BACKGROUND: One of the most severe side effects of solid-organ transplantation is posttransplant lymphoproliferative disease (PTLD). People with human immunodeficiency virus infection (HIV), an immunosuppressive disease comparable to HIV, have a higher chance of developing lymphoma when their peripheral blood contains elevated levels of the immunoglobulins kappa and lambda free light chains (FLCs).
METHODS: This systematic review\'s objective was to monitor associated B lymphoma cells in PTLD patients. In order to find relevant studies published between 1/1/2000 and 1/9/2022, two independent researchers conducted searches (MT, AJ). A literature search of English language publications was conducted using MEDLINE through PubMed, EMBASETM through Ovid, the Cochrane Library, and Trip. In addition to Magiran and SID, we searched KoreaMed and LILACS for literature published in other languages. sFLC or PTLD, transplant, or Electrophoresis are terms used in the search strategy.
RESULTS: A total of 174 studies were selected. After analyzing their correspondence with the required criteria, a final review of five studies was conducted. The manuscript presents current findings on the potential benefits of the clinical applicability of sFLCs in PTLD. While the preliminary results appear promising, the only consistent result is that early-onset PTLD is predicted within the first two years after transplant, a biomarker that could be used to diagnose the condition.
CONCLUSIONS: Therefore, PTLD has been predicted by using the sFLCs. There have been contradictory results to date. Future research could include assessing the quantity of sFLCs and their quality in transplant recipients. In addition to PTLD and complications after transplantation, sFLCs may provide insight into other diseases. To confirm the validity of sFLCs, more studies are needed.