在重症监护病房（ICU）中，嗜酸性粒细胞增多并不少见；然而，DRESS（嗜酸粒细胞增多和全身症状的药物反应）综合征，其特征是对药物的超敏反应，表现为嗜酸性粒细胞增多，全身受累和斑丘疹性皮疹2-6周后暴露于有问题的药物，是一个例外。我们介绍了文献中描述的第一例DRESS综合征以间质性肺炎和质子泵抑制剂（PPI）继发的持续性成人呼吸窘迫综合征（ARDS）的肺部受累。停用不良药物并长期接受全身性皮质类固醇治疗后，患者恢复良好。我们还对迄今为止发表的所有以间质性肺炎形式出现肺部受累的DRESS病例和PPI诱发的DRESS病例进行了系统评价；这些都没有描述肺部受累。
Eosinophilia in not an uncommon findings in the intensive care unit (ICU); however, DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) syndrome, which is characterized by a hypersensitivity reaction to drugs and manifests as eosinophilia, systemic involvement and maculopapular erythematous rash 2-6 weeks after exposure to the offending drug, is an exceptional occurrence. We present the first
case described in the literature of DRESS syndrome with pulmonary involvement in the form of interstitial pneumonitis and persistent adult respiratory distress syndrome (ARDS) secondary to proton pump inhibitors (PPI). The patient made a good recovery after withdrawal of the offending drug and long-term treatment with systemic corticosteroids. We also present a systematic review of all cases of DRESS with pulmonary involvement in the form of interstitial pneumonitis and cases of PPI-induced DRESS published to date; none of these describe pulmonary involvement.
