目的:使用荟萃分析方法检查弱视儿童OCTA的定量测量。方法:PubMed,Embase,和Cochrane图书馆被搜索到2021年3月之前的可用论文。使用加权平均差异(WMD)比较弱视眼与对侧眼或健康对照眼之间的视网膜参数。结果:纳入12项研究。当考虑到Parafovea时,在6×6容积扫描(WMD=-2.12,95CI:-3.24,-0.99)中,弱视眼的微血管密度与健康对照眼相比降低,但在3×3容积扫描(WMD=-1.43,95CI:-2.96,0.11)中没有SCP。在深毛细血管丛(DCP)中,弱视在6×6容积扫描中没有降低血管密度(WMD=-2.22,95CI:-5.86,1.42;I2=79.6%,P=0.008),但是在整个眼睛3×3中观察到差异(WMD=-1.95,95CI:-3.23,-0.67;I2=27.5%,P=0.252)。弱视眼和健康对照眼的中央凹无血管区面积和中央凹厚度没有显着差异。微血管密度没有显著差异,中央凹无血管区,弱视眼睛和同伴眼睛之间的中央凹厚度。结论:根据OCTA,与健康对照眼相比,弱视眼的SCP和DCP的血管密度较低,但不能与对方的眼睛相比。弱视和非弱视之间的中央凹无血管区面积和中央凹厚度没有显着差异。
Purpose: To examine the quantitative measurements of OCTA in children with amblyopia using the meta-analysis methodology. Methods: PubMed, Embase, and Cochrane library were searched for available papers up to March 2021. Weighted mean differences (WMD) were used to compare the retina parameters between the eyes with amblyopia and the contralateral eyes or healthy control eyes. Results: Twelve studies were included. When considering the parafovea, the microvessel density was reduced in amblyopic eyes compared with healthy control eyes in the superficial capillary plexus (SCP) in 6 × 6 volume scan (WMD = -2.12, 95%CI: -3.24, -0.99) but not SCP in 3 × 3 volume scan (WMD = -1.43, 95%CI: -2.96, 0.11). In the deep capillary plexus (DCP), amblyopia did not decrease vessel density in the 6 × 6 volume scan (WMD = -2.22, 95%CI: -5.86, 1.42; I 2 = 79.6%, P = 0.008), but a difference was observed in the whole eye 3 × 3 (WMD = -1.95, 95%CI: -3.23, -0.67; I 2 = 27.5%, P = 0.252). There were no significant differences in the foveal avascular zone area and foveal thickness between amblyopic eyes and healthy control eyes. There were no significant differences in microvessel density, foveal avascular zone area, and foveal thickness between amblyopic eyes and fellow eyes. Conclusion: According to OCTA, amblyopic eyes had lower vessel density in parafoveal SCP and DCP compared with healthy control eyes, but not compared with fellow eyes. There were no significant differences regarding the foveal avascular zone area and foveal thickness between amblyopic and non-amblyopic eyes.