■化生,慢性炎症和结膜下纤维化有利于大泡依赖性青光眼手术的失败。该研究的目的是确定手术后失败风险较高的患者。
■预期,开放式研究,在大学VirgenMacarena医院的青光眼病房进行,2021年4月至11月,至少随访一年。包括38只眼高眼压或慢性开角型青光眼。所有患者在手术室接受术前结膜取样,在局部或局部麻醉下。
■性,年龄,和侧向性;数量,术前药物使用的类型和平均时间;进行的手术类型;细胞学结果和化生程度;关闭气泡的患者百分比。评估气泡闭合与任何其他变量之间的潜在相关性。
■20名女性和18名男性参加,平均年龄67岁。术前降压药物的平均数量为2.7。平均使用时间为90,97+/-48,97个月。大多数患者的细胞学检查正常,8%有炎性浸润,21%有鳞状上皮化生。当涉及气泡失败和细胞学时,我们看到那些手术失败的人,超过一半有细胞学改变。进行了多元逻辑回归,其中我们观察到手术闭合和细胞学改变之间存在统计学显著关联(p=.02)。
■根据这些结果,术前结膜细胞学检查可以帮助预测那些手术成功概率较低的病例。
UNASSIGNED: Metaplasia, chronic inflammation and subconjunctival fibrosis favor failure of bleb-dependent glaucoma surgery. The aim of the study is to identify the patients at a higher risk of post-surgical failure.
UNASSIGNED: Prospective, open study, performed in the Glaucoma Unit of the Hospital Universitario Virgen Macarena, from April to November 2021, with a minimum follow-up of one year. 38 eyes with ocular hypertension or chronic open-angle glaucoma were included. All patients underwent preoperative conjunctival sampling in the operating room, under topical or locoregional anesthesia.
UNASSIGNED: Sex, age, and laterality; number, type and mean time of preoperative drugs use; type of surgery performed; cytology results and degree of metaplasia; percentage of patients in whom the bleb was closed. Evaluation of potential correlation between bleb closure and any of the other variables.
UNASSIGNED: 20 women and 18 men participated, with a mean age of 67 years. The mean number of preoperative hypotensive drugs was 2.7. The mean time of use was 90,97 +/- 48,97 months. Most patients had normal cytology, 8% had inflammatory infiltrate and 21% had squamous metaplasia. When relating bleb failure and cytology, we saw that in those who failed surgery, more than half had cytological alterations. A multiple logistic regression was performed, in which we observed that there was statistically significant association (p = .02) between surgical closure and altered cytology.
UNASSIGNED: According to these results, preoperative conjunctival cytology can help predict those cases with a lower probability of surgical success.