背景:体内和体外研究表明成纤维细胞生长因子(FGF)和FGF受体(FGFR)在神经存活中的重要作用,神经发生,氧化应激,和情绪行为。然而,关于FGF和FGFR在重度抑郁障碍(MDD)病理生理学中作用的证据仍然有限,尚无定论.
目的:本初步荟萃分析旨在研究MDD患者外周或中枢FGF和FGFR水平的变化。
方法:通过PubMed和ClinicalTrials.gov平台进行电子研究。
方法:我们使用纳入标准:讨论FGF水平比较的文章,在外围或中心环境中,MDD患者和健康对照(HC);关于人体临床试验的文章;和病例对照试验。病例报告或系列和非临床试验被排除。
方法:使用全面的文献检索,比较MDD和HC患者的FGF/FGFR水平。包括关于外周FGF-2和3对中枢FGF-2和FGFR1水平的四项研究。
结果:结果显示,MDD患者的外周FGF-2蛋白和中枢FGFR1RNA水平明显高于HC(分别为P=0.005和0.006),但与临床变量没有显著关联。MDD和HC患者的中枢FGF-2水平也没有显着差异(P=0.180)。
结论:该研究有少量纳入研究的局限性,缺乏对FGF随治疗变化的荟萃分析,缺乏关于外周FGF-2与中枢FGF-2水平相关性的直接证据。
结论:这项初步的荟萃分析为未来研究MDD之间的关系指出了一个新的方向,氧化应激,FGF家族。
BACKGROUND: In vivo and in vitro studies demonstrate the important roles of fibroblast growth factor (FGF) and FGF receptors (FGFRs) in neural survival, neurogenesis, oxidative stress, and emotional behavior. However, evidence on the role of FGF and FGFR in the pathophysiology of major depressive disorder (MDD) remains limited and inconclusive.
OBJECTIVE: This preliminary meta-analysis aimed to examine changes in peripheral or central FGF and FGFR levels in patients with MDD.
METHODS: Electronic research through platform of PubMed and ClinicalTrials.gov.
METHODS: We used the inclusion criteria: articles discussing the comparisons of FGF levels, either in peripheral or central environment, in patients with MDD and in healthy controls (HC); articles on clinical trials in humans; and case-control trials. Case reports or series and nonclinical trials were excluded.
METHODS: Using a thorough literature search, the FGF/FGFR levels in patients with MDD and HC were compared. Four studies on peripheral FGF-2 and 3 on central FGF-2 and FGFR1 levels were included.
RESULTS: The findings reveal significantly higher peripheral FGF-2 protein and central FGFR1 RNA levels in patients with MDD than in HC (P = 0.005 and 0.006, separately), but no significant association with clinical variables. There was also no significant difference in the central FGF-2 levels in patients with MDD and in HC (P = 0.180).
CONCLUSIONS: The study has limitations of a small number of included studies, lack of meta-analysis of the FGF changes along with treatment, and lack of direct evidence on correlation of peripheral FGF-2 with central FGF-2 levels.
CONCLUSIONS: This preliminary meta-analysis points out a new direction for future studies investigating the relationship among MDD, oxidative stress, and the FGF family.