计算模型在心血管血液动力学研究中具有公认的实用性,在医学研究中的应用,越来越多,改善心血管疾病的诊断和治疗。迄今为止开发的大多数心血管模型都是成人循环系统的;然而,围产期是独一无二的,因为心血管生理经历了胎儿循环的剧烈变化,在出生过渡期间,进入新生儿生活。在此期间可能还会有进一步的并发症:例如,早产(定义为妊娠37周前出生)有短期心血管不稳定的风险,并且与终生心血管风险增加相关.这里,我们回顾了早期心血管系统的计算模型,它们迄今为止的应用以及这些模型的潜在改进和增强。我们提出了一个路线图,用于开发一个跨越胎儿的开源心血管模型,围产期,和产后时期。本文分为:心血管疾病>计算模型心血管疾病>生物医学工程先天性疾病>计算模型。
Computational modeling has well-established utility in the study of cardiovascular hemodynamics, with applications in medical research and, increasingly, in clinical settings to improve the diagnosis and treatment of cardiovascular diseases. Most cardiovascular models developed to date have been of the adult circulatory system; however, the perinatal period is unique as cardiovascular physiology undergoes drastic changes from the fetal circulation, during the birth transition, and into neonatal life. There may also be further complications in this period: for example, preterm birth (defined as birth before 37 completed weeks of gestation) carries risks of short-term cardiovascular instability and is associated with increased lifetime cardiovascular risk. Here, we
review computational models of the cardiovascular system in early life, their applications to date and potential improvements and enhancements of these models. We propose a roadmap for developing an open-source cardiovascular model that spans the fetal, perinatal, and postnatal periods. This article is categorized under: Cardiovascular Diseases > Computational Models Cardiovascular Diseases > Biomedical Engineering Congenital Diseases > Computational Models.