最近,已经证明SARS-CoV-2具有感染多种物种的能力。这项工作旨在确定国内和野生动物中SARS-CoV-2感染的临床症状。对家猫和野猫的病例报告进行了基于PRISMA的系统评价,关于实验性感染的报告,数据库中的病例报告,预印本和发布的新闻稿。对数据进行描述性统计分析。共256条,分析了63份详细的官方报告和2篇有关SARS-CoV-2在家猫和野猫中感染的新闻文章,其中最终包括19篇文章和65份报告。在家猫中,大多数猫感染可能是无症状的,报告的感染动物中有46%有症状,主要表现为呼吸体征,如打喷嚏和咳嗽。在野生猫科动物中,呼吸道临床体征最常见,高达96.5%的受影响动物出现咳嗽。值得注意的是,到目前为止,据报道,有症状的SARS-CoV-2感染动物属于两个不同的亚科(Phanterinae和Felinae),在Felidae家族中,多达五种不同的猫科动物受到影响。报告的结果表明,在猫科动物中出现的迹象显示出与人类相似的进展,表明病毒周期与不同物种病毒靶组织之间的关系。虽然病毒向与动物种群接触的人类传播尚未报道,泄漏可能导致免疫逃逸突变体的出现,这可能对公众健康构成风险。尽管在确定猫科动物SARS-CoV-2感染的典型临床表现方面有明确的结果,关于这一主题的详细学术报告和论文数量很少。因此,对这些病例的进一步描述将允许未来更准确和统计上稳健的临床方法.
Recently, it has been proved that SARS-CoV-2 has the ability to infect multiple species. This work was aimed at identifying the clinical signs of SARS-CoV-2 infection in domestic and wild
felids. A PRISMA-based systematic
review was performed on case reports on domestic and wild cats, reports on experimental infections, case reports in databases, preprints and published press releases. Descriptive statistical analysis of the data was performed. A total of 256 articles, 63 detailed official reports and 2 press articles on SARS-CoV-2 infection in domestic and wild cats were analyzed, of which 19 articles and 65 reports were finally included. In domestic cats, most cats\' infections are likely to be asymptomatic, and 46% of the reported infected animals were symptomatic and predominantly presented respiratory signs such as sneezing and coughing. In wild felines, respiratory clinical signs were most frequent, and up to 96.5% of the reported affected animals presented coughing. It is noteworthy that, to date, symptomatic animals with SARS-CoV-2 infection have been reported to belong to two different subfamilies (Phanterinae and Felinae), with up to five different felid species affected within the Felidae family. Reported results evince that the signs developed in
felids show similar progression to those occurring in humans, suggesting a relationship between the viral cycle and target tissues of the virus in different species. While viral transmission to humans in contact with animal populations has not been reported, spill-back could result in the emergence of immune-escape mutants that might pose a risk to public health. Despite the clear results in the identification of the typical clinical picture of SARS-CoV-2 infection in felines, the number of detailed academic reports and papers on the subject is scarce. Therefore, further description of these cases will allow for more accurate and statistically robust clinical approaches in the future.