■探讨脂肪酸结合蛋白4(FABP4)水平与糖尿病前期向正常糖耐量(NGT)逆转之间的关系。
■对398名具有完整信息的参与者进行了为期两年的回顾性队列研究。随访2年后,将这398名参与者分为NGT组和葡萄糖代谢异常(AGM)组。确定FABP4的基线水平,使用非条件逻辑回归模型研究了FABP4在预测糖尿病前期向NGT逆转中的作用.
■在两年的随访期内,37.4%(149/398)的参与者从糖尿病前期恢复到NGT。AGM患者的FABP4基线水平高于NGT患者。FABP4的基线水平与糖尿病前期向NGT的逆转呈显著负相关。在调整了年龄之后,性别,体重指数和腰臀比,空腹血糖水平(FBG)[比值比(OR)0.336,95%置信区间(CI)(0.196-0.576)],激发后2小时血糖(2hBG)[OR0.697,95%CI(0.581-0.837)],基线时FABP4[OR0.960,95%CI(0.928-0.993)]是糖尿病前期逆转为NGT的显著独立预测因子.FABP4受试者工作特征曲线的曲线下面积(AUC)值为0.605(95%CI:0.546-0.665),FABP4联合FBG和2hBG的AUC为0.716(95%CI:0.663-0.769)。
■较高的FABP4基线水平与糖尿病危险因素的不利情况呈正相关,与糖尿病前期向NGT的逆转呈负相关。FABP4,FBG和2hBG是糖尿病前期向NGT逆转的预测因子。
UNASSIGNED: To explore the relationship between the level of fatty acid-binding protein 4 (FABP4) and reversion from prediabetes to normal glucose tolerance (NGT).
UNASSIGNED: A two-year retrospective cohort
study was conducted on 398 participants with complete information. These 398 participants were divided into an NGT group and an abnormal glucose metabolism (AGM) group after 2 years of follow-up. The baseline level of FABP4 was determined, and the role of FABP4 in predicting reversion from prediabetes to NGT was investigated using an unconditional logistic regression model.
UNASSIGNED: Over the two-year follow-up period, 37.4% (149/398) of the participants reverted from prediabetes to NGT. The participants with AGM had a higher baseline level of FABP4 than those with NGT. The baseline level of FABP4 was significantly negatively correlated with reversion from prediabetes to NGT. After adjusting for age, sex, body mass index and waist-to-hip ratio, the level of fasting blood glucose (FBG) [odds ratio (OR) 0.336, 95% confidence interval (CI) (0.196-0.576)], 2-h post-challenge blood glucose (2hBG) [OR 0.697, 95% CI (0.581-0.837)], and FABP4 [OR 0.960, 95% CI (0.928-0.993)] at baseline were significant independent predictors of reversion from prediabetes to NGT. The area under the curve (AUC) value of the receiver operating characteristic curve for FABP4 was 0.605 (95% CI: 0.546-0.665), and the AUC for FABP4 combined with FBG and 2hBG was 0.716 (95% CI: 0.663-0.769).
UNASSIGNED: A higher baseline level of FABP4 was positively correlated with an adverse profile of diabetes risk factors and negatively correlated with reversion from prediabetes to NGT. FABP4, FBG and 2hBG were predictors of reversion from prediabetes to NGT.