UNASSIGNED:各种研究表明Fas细胞表面死亡受体/Fas配体(FAS/FASL)变体与多种类型的癌症之间存在相关性。本研究旨在调查FAS-670A/G和FASL-844C/T之间的关联以及两种变体对伊朗西部库尔德人胃癌(GC)风险的协同作用。
UNASSIGNED:本研究是通过聚合酶链反应-限制性片段长度多态性技术,使用MvaI和BsrDI限制性酶对98例GC患者和103例健康对照个体进行的。
UNASSIGNED:根据获得的结果,检测到GC患者和对照组之间FASL多态性存在显著关联(P=0.008).此外,GC患者与对照组之间的FAS多态性频率没有显着差异。FASL多态性中的共显性和显性模型显示出对GC的显着保护作用[优势比(OR)=0.307,95%置信区间(CI)(0.134-0.705),P=0.005;OR=0.205,95%CI(0.058-0.718),P=0.013,OR=0.295,95%CI(0.129-0.673),P=0.004对于共显性CC与CT,共显性CC与TT和显性,分别]。此外,FAS-670G和FASL-844T等位基因的存在代表了对GC发生的显着保护作用[OR=0.420,95%CI(0.181-0.975),P=0.043]。
未经批准:到目前为止,我们认为这是第一项研究,结果表明,FASL基因变异及其与FAS基因的协同作用可能与伊朗西部库尔德人群的GC风险有关。
Various studies have suggested a correlation between Fas cell surface death receptor/Fas ligand (FAS/FASL) variants and multiple types of cancers. The present study aimed to investigate the association between FAS-670A/G and FASL-844C/T and the synergistic effects of both variants on the risk of gastric cancer (GC) in the Kurdish population of west of Iran.
This study was conducted by polymerase chain reaction-restriction fragment length polymorphism technique using MvaI and BsrDI restriction enzymes in 98 GC patients and 103 healthy control individuals.
According to the obtained results, a significant association (P=0.008) of FASL polymorphism among GC patients and the control group was detected. Furthermore, no significant differences were found in the FAS polymorphism frequencies between GC patients and the control group. Codominant and dominant models in FASL polymorphism showed significant protective effects against GC [odds ratio (OR)=0.307, 95% confidence interval (CI) (0.134-0.705), P=0.005; OR=0.205, 95% CI (0.058-0.718), P=0.013 and OR=0.295, 95% CI (0.129-0.673), P=0.004 for models of codominant CC vs. CT, codominant CC vs. TT and dominant, respectively]. Furthermore, the presence of both FAS-670G and FASL-844T alleles represented a significant protective effect against GC occurrence [OR=0.420, 95% CI (0.181-0.975), P=0.043].
So far, we believe this is the first study, the results of which suggest that FASL gene variation and its synergistic effects with FAS gene could be associated with the risk of GC in the Kurdish population in the west of Iran.