Lumbar degenerative spondylolisthesis (LDS) is a common spinal disease. LDS has been differentiated into dynamic (unstable) and static (stable) spondylolisthesis. Standing flexion/extension lumbar spine radiographs are the best investigation to detect presence of dynamic spondylolisthesis. Magnetic resonance imaging is the investigation of choice to show lumbar canal stenosis and disc prolapse but it can miss dynamic LDS. Studies have shown good association between presence of facet fluid (FF) and dynamic spondylolisthesis.
A systematic review and meta-analysis were performed. All studies describing the relationship between FF and degenerative spondylolisthesis as measured on dynamic radiographs or kinematic magnetic resonance imaging were included.
Fourteen articles met the inclusion criteria. A total of 1065 patients were included in the meta-analysis. Of the patients with unstable spondylolisthesis, 71% had FF, whereas only 22% of the patients with stable spondylolisthesis had FF. The combined pooled odds ratio for unstable spondylolisthesis in the presence of FF was 7.55 (3.61-15.08; P <0.00001). The pooled standard mean difference in the FF size in the patients with unstable and stable spondylolisthesis was 0.97 mm (0.38-1.57; P = 0.001).
FF has positive correlation with the presence of dynamic LDS and the probability of dynamic LDS increases as the size of FF increases. The probability of having a dynamic spondylolisthesis in patients with FF >1 mm is 8 times that of patients with no FF. Standing flexion extension radiographs should be performed in patients with FF >1 mm.