发育和癌症具有多种功能特征，例如EMT，细胞迁移，血管生成,和组织重塑。此外,注意到许多细胞信号通路协调发育过程并促进肿瘤进展。转录因子的叉头盒超家族由高度保守的DNA结合域组成，它与特定的DNA序列结合，并在成年组织的同质性和胚胎发育过程中发挥重要作用，分化,新陈代谢，扩散,凋亡，迁移,和入侵。有趣的是,各种研究都暗示了福克斯家族主要成员的作用，如FOXP，FOXO,和FOXA在癌症开始和转移期间。FOXI3是Forkhead家族的一员，影响胚胎发生，发展,和骨骼重塑；然而，没有研究报告在癌症中的作用。在这次审查中,我们总结了FOXI3在胚胎发生和骨发育中的作用，并讨论了其在癌症进展中的潜在参与，重点是骨转移。此外，我们假设FOXI3在实体瘤骨转移发展中的潜在作用机制.
Development and cancer share a variety of functional traits such as EMT, cell migration, angiogenesis, and tissue remodeling. In addition, many cellular signaling pathways are noted to coordinate developmental processes and facilitate aspects of tumor progression. The Forkhead box superfamily of transcription factors consists of a highly conserved DNA binding domain, which binds to specific DNA sequences and play significant roles during adult tissue homoeostasis and embryogenesis including development, differentiation, metabolism, proliferation, apoptosis, migration, and invasion. Interestingly, various studies have implicated the role of key Fox family members such as FOXP, FOXO, and FOXA during cancer initiation and metastases.
FOXI3, a member of the Forkhead family affects embryogenesis, development, and bone remodeling; however, no studies have reported a role in cancer. In this
review, we summarize the role of
FOXI3 in embryogenesis and bone development and discuss its potential involvement in cancer progression with a focus on the bone metastasis. Moreover, we hypothesize possible mechanisms underlying the role of
FOXI3 in the development of solid tumor bone metastasis.
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