FLASH-RT

FLASH - RT
  • 文章类型: Journal Article
    在新兴的FLASH放射治疗中以超高剂量率递送的电离辐射脉冲可导致高强度低频热声发射,其可能具有生物影响。这项研究旨在提供有关FLASH放射治疗期间预期的热声发射及其引起声空化的可能性的见解。计算机模拟研究了由脉冲电子束的能量沉积引起的声波特性,该特性类似于先前的临床前FLASH放射治疗研究及其在鼠头状体模中的传播。结果表明,由于被照射物体中的共振,产生的压力足以产生声空化。这表明热声学可能,在一些辐照场景中,如果在治疗计划阶段不考虑,则会导致广泛误解的FLASH效应或导致不良反应。
    Ionizing radiation pulses delivered at ultra-high dose rates in emerging FLASH radiotherapy can result in high-intensity low-frequency thermoacoustic emissions that may have a biological impact. This study aims at providing insights into the thermoacoustic emissions expected during FLASH radiotherapy and their likelihood of inducing acoustic cavitation. The characteristics of acoustic waves induced by the energy deposition of a pulsed electron beam similar to previous pre-clinical FLASH radiotherapy studies and their propagation in murine head-like phantoms are investigated in-silico. The results show that the generated pressures are sufficient to produce acoustic cavitation due to resonance in the irradiated object. It suggests that thermoacoustics may, in some irradiation scenarios, contribute to the widely misunderstood FLASH effect or cause adverse effects if not taken into account at the treatment planning stage.
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