背景:与孕激素受体阴性的脑膜瘤相比,孕激素受体阳性的脑膜瘤具有低复发率和良好预后。本研究旨在确定孕激素在脑膜瘤中的表达及其与临床病理特征的关系。
方法:这是一项在Muhimbili国立医院进行的基于实验室的横断面研究。该研究包括2010年1月至2014年12月在组织学基础上证实患有脑膜瘤的112例福尔马林固定石蜡包埋组织块。使用准备使用的初级单克隆孕酮受体抗体(IR068Dako)测试孕酮受体的免疫组织化学表达。χ2检验用于确定临床病理特征与孕激素受体表达之间的关系。双尾P<0.05被认为是显著的。
结果:患者的平均年龄为45.5±3.601岁,和多数(66.1%,n=74)年龄在31至60岁之间。此外,大多数患者(60%,n=67)在这项研究中是女性。超过三分之一的病例(34.8%,n=39)包括脑膜腺瘤亚型,大多数病例(89.3%,n=100)为I级。孕酮表达的患病率为54.5%(n=61),仅年龄与孕激素受体表达相关(P=0.043)。
结论:本研究中I级病例孕激素受体高表达的发现表明脑膜瘤中孕激素受体的表达具有预后价值,可以在评估患者的治疗时加以考虑。在所有恶性肿瘤中缺乏孕激素受体的表达是有趣的,需要进一步的研究来研究其预后作用。
BACKGROUND: Meningiomas that are progesterone receptor positive have a low recurrence rate and good prognosis compared to those that are progesterone receptor negative. This
study aimed to determine the prevalence of expression of progesterone in meningiomas and its association with clinicopathological characteristics.
METHODS: This was a cross-sectional laboratory-based
study that was conducted at Muhimbili National Hospital. The
study included 112 formalin-fixed paraffin-embedded tissue blocks of patients who were confirmed to have meningiomas on histological basis from January 2010 to December 2014. Immunohistochemical expression of progesterone receptor was tested using a primary monoclonal progesterone receptor antibody ready to use (IR 068 Dako). The χ2 test was used to determine the association between clinicopathological characteristics and progesterone receptor expression. A 2-tailed P < 0.05 was considered significant.
RESULTS: The mean age of the patients was 45.5 ± 3.601 years, and majority (66.1%, n = 74) were in the age group between 31 and 60 years. Also, majority of the patients (60%, n = 67) in this
study were females. Over one-third of the cases (34.8%, n = 39) comprised of meningotheliomatous subtype, and majority of the cases (89.3%, n = 100) were of grade I. The prevalence of progesterone expression was 54.5% (n = 61), and only age was associated with progesterone receptor expression (P = 0.043).
CONCLUSIONS: The finding of high expression of the progesterone receptor for grade I cases in this
study indicates that progesterone receptor expression in meningiomas is of prognostic value and may be considered when evaluating patients for management. Lack of expression of progesterone receptor in all the malignant cases is intriguing and needs further studies that can investigate its prognostic role.