胶质瘤是脑最常见的原发性肿瘤。它们可以分为II-IV级星形细胞瘤和II-III级少突胶质细胞瘤，根据他们的组织分子特征。预后和治疗高度依赖于分级和充分鉴定的预后和/或预测性分子标志物。多参数MRI,包括弥散加权成像，灌注,和MR光谱学，在胶质瘤特定分子亚群的非侵入性表征中显示出越来越高的价值。放射性标记的氨基酸类似物，如18F-FET，在神经胶质瘤成像中也被证明是有价值的。这些示踪剂不仅通过检测弥漫性神经胶质瘤的去分化区域而有助于诊断过程，但是这种技术在神经胶质瘤的随访中也很有价值，因为它可以区分假性进展和真正的肿瘤进展。由于多参数MRI和18F-FETPET是互补的成像技术，PET-MRI成像在原发性脑肿瘤的神经肿瘤成像中可能具有协同作用.这对两个初级分期都有价值，以及在治疗和随访期间。
Gliomas are the most frequent primary tumors of the brain. They can be divided into grade II-IV astrocytomas and grade II-III oligodendrogliomas, based on their histomolecular profile. The prognosis and treatment is highly dependent on grade and well-identified prognostic and/or predictive molecular markers. Multi-parametric MRI, including diffusion weighted imaging, perfusion, and MR spectroscopy, showed increasing value in the non-invasive characterization of specific molecular subsets of gliomas. Radiolabeled amino-acid analogues, such as 18F-FET, have also been proven valuable in glioma imaging. These tracers not only contribute in the diagnostic process by detecting areas of dedifferentiation in diffuse gliomas, but this technique is also valuable in the follow-up of gliomas, as it can differentiate pseudo-progression from real tumor progression. Since multi-parametric MRI and 18F-FET PET are complementary imaging techniques, there may be a synergistic role for PET-MRI imaging in the neuro-oncological imaging of primary brain tumors. This could be of value for both primary staging, as well as during treatment and follow-up.
