背景:原发性脊髓肿瘤是罕见且异质性的,他们的患病率在研究中有所不同。很少有文章评估患病率,特点,和拉丁美洲人群脊髓肿瘤的组织学类型。本研究旨在分析在巴西一家机构接受手术治疗的一系列连续诊断为原发性脊髓肿瘤的患者的组织学类型和临床方面,并将其与文献进行比较。
方法:这是一个案例系列研究,回顾性分析1997年1月至2021年4月在一个中心接受原发性脊髓肿瘤手术治疗的所有连续成人患者。分析的数据包括手术年龄,性别,解剖位置,组织病理学诊断,临床表现,出院时的神经状况。
结果:共有104名患者(53名女性[51.0%];平均年龄,49.0±16.7年[范围,19-87岁])被纳入分析。在肿瘤中,83.7%为良性,36.5%累及胸椎;硬膜内髓外病变占肿瘤的52.9%,最常见的是神经鞘瘤(26.9%)和脑膜瘤(18.3%)。在患者中,55%和50%出现疼痛和运动障碍,分别,在术后即刻和出院时,缺陷改善率大于恶化率。
结论:与其他研究相比,我们的系列研究强调了原发性脊髓肿瘤的异质性。需要进一步的大规模人群研究来阐明这种疾病的流行病学。
BACKGROUND: Primary spinal cord tumors are rare and heterogeneous, and their prevalence varies among the studies. Few articles have evaluated the prevalence, characteristics, and histological types of spinal cord tumors in Latin American populations. This
study aimed to analyze the histological types and clinical aspects of a series of consecutive patients diagnosed with primary spinal cord tumors who underwent surgical treatment in a single Brazilian institution and to compare them with the literature.
METHODS: This is a case series
study, with retrospective analysis of all consecutive adult patients who underwent surgical treatment for primary spinal cord tumors in a single center between January 1997 and April 2021. Data analyzed included age at surgery, sex, anatomical location, histopathological diagnosis, clinical presentation, and neurological status at discharge.
RESULTS: A total of 104 patients (53 women [51.0%]; mean age, 49.0 ± 16.7 years [range, 19-87 years]) were included in the analysis. Among the tumors, 83.7% were benign, and 36.5% involved the thoracic spine; intradural extramedullary lesions comprised 52.9% of the tumors, and the most prevalent were schwannomas (26.9%) and meningiomas (18.3%). Among the patients, 55% and 50% presented with pain and motor deficit, respectively, and the deficit improvement rate was greater than the worsening rate at the immediate postoperative period and discharge.
CONCLUSIONS: Our series highlights the heterogeneity of primary spinal cord tumors compared to other studies. Further large population studies are necessary to elucidate the epidemiology of this disease.