目的：评价体外复苏成熟卵母细胞(IVM)的发育能力。
方法：PubMed，Embase,和SCOPUS使用相关关键词和医学主题标题术语系统地搜索同行评审的原始论文。使用纽卡斯尔-渥太华量表评估研究质量。通过应用随机效应模型计算具有95%置信区间的赔率比。主要结果是受精和囊胚率。次要结果包括异常受精，乳沟,整倍体,临床妊娠,和活产率。
结果：24项研究纳入荟萃分析。拯救IVM后成熟的卵母细胞显示受精显著减少，乳沟,囊胚形成,与同胞体内成熟卵母细胞相比，临床妊娠率。在整倍体胚泡移植中，整倍体和活产率没有发现显着差异。在可怜的响应者中，使用体外成熟的GV观察到受精率降低，但未观察到体外成熟的MI。发现与<6个孵育小时相比,MI成熟过夜时的切割速率降低。
结论：我们的结果显示，在拯救IVM后成熟的卵母细胞的发育能力受损。然而,在可怜的响应者中，抢救IVM可以最大限度地提高治疗效率.值得注意的是,我们的数据表明，使用体外MI在6个孵育小时内成熟。
背景：CRD42023467232.
OBJECTIVE: To assess the developmental competence of oocytes matured following rescue in vitro maturation (IVM).
METHODS: PubMed, EmBASE, and SCOPUS were systematically searched for peer-reviewed original papers using relevant keywords and Medical Subject Heading terms. Study quality was assessed using the Newcastle-Ottawa Scale. Odds ratios with a 95% confidence interval were calculated by applying a random effects model. The primary outcomes were fertilization and blastulation rates. Secondary outcomes included abnormal fertilization, cleavage,
euploidy, clinical pregnancy, and live-birth rates.
RESULTS: Twenty-four studies were included in the meta-analysis. The oocytes matured following rescue IVM showed significantly reduced fertilization, cleavage, blastulation, and clinical pregnancy rates compared to sibling in vivo-matured oocytes. No significant differences were found for the
euploidy and live-birth rates in euploid blastocyst transfer. In poor responders, a reduced fertilization rate was observed using in vitro-matured GV but not with in vitro-matured MI. A reduced cleavage rate in MI matured overnight compared to < 6 incubation hours was found.
CONCLUSIONS: Our results showed compromised developmental competence in oocytes matured following rescue IVM. However, in poor responders, rescue IVM could maximize the efficiency of the treatment. Notably, our data suggests using in vitro MI matured within 6 incubation hours.
BACKGROUND: CRD42023467232.
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