目的:本研究使用国际帕金森与运动障碍协会(IPMDS)发布的震颤分类标准,包括美国耳鼻咽喉头颈外科学会(AAO-HNS)的喉特征,对声带震颤(VT)患者的临床表型进行了表征。
方法:从2017年至2019年的参与者病历中提取VT表型描述符。临床表型描述包括:(a)首次任命的主要投诉和纪律,(b)人口统计,(c)震颤体分布,条件,频率,和进步,(d)加剧/缓解因素,(e)治疗方法,和(g)神经合并症。进行了描述性统计。
结果:在符合入选标准的179人中,2/3为女性;震颤发作受声音(43%)或四肢(32%)影响,有2/3的震颤持续时间为3年或更长时间。原发性室性心动过速者首先看到耳鼻咽喉科或语言病理学(59%),而患有原发性四肢/头部震颤的人首先看到神经病学(36%)。文献通常省略了震颤的临床特征,例如(a)观察到的震颤状况(64%),(b)喉部特征(64%),和(c)震颤频率(92%)。因此,室性心动过速分类是基于49%患者的合并症(即,特发性震颤(48%),肌张力障碍(72%),和帕金森病(100%)),32%的人没有足够的文件进行分类。
结论:大多数室性心动过速患者无法根据记录的临床特征进行分类,强调需要对影响言语结构的震颤进行一致的多学科评估。震颤的主要部位决定了所见的第一个学科。最常见的室性心动过速分类包括特发性震颤(47%),肌张力障碍(28%),帕金森病(7%),和孤立性室性心动过速(19%)。
方法:4.
OBJECTIVE: This study characterized the clinical phenotypes of individuals with vocal tremor (VT) using tremor classification criteria published by the International Parkinson and Movement Disorder Society (IPMDS) including laryngeal features from the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS).
METHODS: VT phenotypic descriptors were extracted from participant medical records from 2017 to 2019. Clinical phenotype descriptors included the: (a) chief complaint and discipline for the first appointment, (b) demographics, (c) tremor body distribution, condition, frequency, and progression, (d) exacerbating/alleviating factors, (e) treatment approaches, and (g) neurologic comorbidities. Descriptive statistics were conducted.
RESULTS: Of 179 meeting inclusion criteria, 2/3 were female; tremor onset affected voice (43%) or extremity (32%) and 2/3 were documented with tremor duration of 3 years or more. Those with primary VT first saw otolaryngology or speech language pathology (59%), whereas those with primary extremity/head tremor first saw neurology (36%). Documentation commonly omitted tremor clinical features such as (a) observed conditions of tremor (64%), (b) laryngeal features (64%), and (c) tremor frequency (92%). Thus, VT classification was based on comorbidity in 49% of patients (ie, essential tremor (48%), dystonia (72%), and Parkinson\'s disease (100%)) and 32% had inadequate documentation to classify.
CONCLUSIONS: The majority of individuals with VT were unable to be classified based on documented clinical features highlighting the need for consistent multidisciplinary assessment of tremor affecting speech structures. The primary site of tremor determined the first discipline seen. Most commonly classified VT categories included essential tremor (47%), dystonia (28%), Parkinsonism (7%), and isolated VT (19%).
METHODS: 4.