HER4是一种受体酪氨酸激酶,是正常身体系统如心血管系统进化所必需的,紧张,和内分泌系统,尤其是乳腺.它通过配体结合激活并激活MAPK和PI3K/AKT途径。HER4通常在许多人体组织中表达,成人和胎儿。了解HER4在许多疾病治疗中的作用很重要。还对HER4在肿瘤中的作用及其肿瘤抑制功能进行了许多研究。大多数情况下,HER4激酶的过度表达导致癌症发展。在本文中,我们回顾了结构,location,配体,HER4的生理功能及其与不同癌症类型的关系。对2016年至今主要报道的HER4抑制剂进行了综述。
HER4 is a receptor tyrosine kinase that is required for the evolution of normal body systems such as cardiovascular, nervous, and endocrine systems, especially the mammary glands. It is activated through ligand binding and activates MAPKs and PI3K/AKT pathways. HER4 is commonly expressed in many human tissues, both adult and fetal. It is important to understand the role of HER4 in the treatment of many disorders. Many studies were also conducted on the role of HER4 in tumors and its tumor suppressor function. Mostly, overexpression of HER4 kinase results in cancer development. In the present article, we reviewed the structure, location, ligands, physiological functions of HER4, and its relationship to different cancer types. HER4 inhibitors reported mainly from 2016 to the present were reviewed as well.