背景:造血干细胞移植或实体器官移植后,患者有发生爱泼斯坦-巴尔病毒阳性移植后淋巴增殖性疾病(EBV+PTLD)的风险,这是一种非常罕见且可能致命的血液系统恶性肿瘤。EBV+PTLD的常见治疗包括单独使用利妥昔单抗或联合化疗。鉴于对这一人群的具体考虑,包括需要移植的潜在疾病的严重程度,移植手术的严峻性,以及移植器官的风险,有一组EBV+PTLD患者可能不适合化疗;然而,这些患者的特征信息有限。这项研究旨在就在现实世界中可能不适合化疗的患者的关键特征达成专家共识。
方法:进行了两轮改良的Delphi研究,以在具有治疗EBVPTLD专业知识的临床医生之间达成共识。在有针对性的文献综述中确定的文章指导了第1轮和第2轮主题和相关陈述的发展。第一轮声明的共识阈值为75.0%。如果在第一轮中达成共识,则在第二轮中不再进一步讨论该声明。第2轮的共识阈值中等(62.5-75.0%),强(87.5%),或完成(100.0%)。
结果:该小组由来自六个欧洲国家的8名临床医生(7名血液学家/血液肿瘤学家)组成。该小组就以下主题生成了43项共识建议的最终列表:用于描述可能不适合化疗的患者的术语;人口统计学特征;器官移植特征;排除使用化疗的合并症;EBV+PTLD特征;以及与治疗相关的死亡率和发病率相关的因素。
结论:这个改良的Delphi小组成功地就EBV+PTLD患者化疗可能不合适的关键主题和陈述达成了共识。这些建议将告知临床医生并帮助治疗EBVPTLD。
Following hematopoietic stem cell transplantation or solid organ transplantation, patients are at risk of developing Epstein-Barr virus-positive post-transplant lymphoproliferative disease (EBV+ PTLD), which is an ultra-rare and potentially lethal hematologic malignancy. Common treatments for EBV+ PTLD include rituximab alone or combined with chemotherapy. Given specific considerations for this population, including severity of the underlying condition requiring transplant, the rigors of the transplant procedure, as well as risks to the transplanted organ, there is a group of patients with EBV+ PTLD for whom chemotherapy may be inappropriate; however, there is limited information characterizing these patients. This study aimed to reach expert
consensus on the key characteristics of patients for whom chemotherapy may be inappropriate in a real-world setting.
A two-round modified Delphi study was conducted to reach
consensus among clinicians with expertise treating EBV+ PTLD. Articles identified in a targeted literature review guided the development of round 1 and 2 topics and related statements. The
consensus threshold for round 1 statements was 75.0%. If
consensus was achieved in round 1, the statement was not discussed further in round 2. The
consensus thresholds for round 2 were moderate (62.5-75.0%), strong (87.5%), or complete (100.0%).
The panel was composed of a total of eight clinicians (seven hematologists/hemato-oncologists) from six European countries. The panel generated a final list of 43 consensus recommendations on the following topics: terminology used to describe patients for whom chemotherapy may be inappropriate; demographic characteristics; organ transplant characteristics; comorbidities that preclude the use of chemotherapy; EBV+ PTLD characteristics; and factors related to treatment-related mortality and morbidity.
This modified Delphi panel successfully achieved consensus on key topics and statements that characterized patients with EBV+ PTLD for whom chemotherapy may be inappropriate. These recommendations will inform clinicians and aid in the treatment of EBV+ PTLD.