使用皮肤贴剂递送药物是可靠的,并且没有与渗透促进剂相同的问题,这有助于药物通过皮肤,但由于皮肤的天然屏障而挣扎。需要增加局部生物利用度以增强药物吸收的策略。天然化合物通过暂时降低皮肤屏障抗性和改善药物吸收提供了有希望的解决方案。天然物质允许更广泛的药物通过角质层分布,提供了一种可靠的方法来增强透皮给药。天然物质作为渗透性增强剂具有明显的优势。它们在药理学上是有效和安全的,不活跃,非过敏性,无刺激性。这些特性确保了它们的适用性而不会造成不利影响。天然化合物容易获得并且被身体良好耐受。研究天然化学物质的结构-活性关系的研究已经证明了显著的增强作用。通过了解化学成分和增强剂活性之间的联系,研究人员可以确定有效的天然化合物,以提高药物的渗透。总之,目前的研究集中在利用天然化合物作为透皮治疗系统的渗透促进剂。这些物质提供安全性,无毒性,药理活性低下,无刺激。通过结构-活动关系调查,在增强药物递送方面取得了有希望的进展。使用天然化合物具有改善经皮递送药物的渗透的巨大潜力。
Using skin patches to deliver drugs is dependable and doesn\'t have the same issues as permeation enhancers, which help drugs get through the skin but struggle because of the skin\'s natural barrier. Strategies are required to increase topical bioavailability to enhance drug absorption. Natural compounds offer a promising solution by temporarily reducing skin barrier resistance and improving drug absorption. Natural substances allow a wider variety of medications to be distributed through the stratum corneum, offering a dependable approach to enhancing transdermal drug delivery. Natural substances have distinct advantages as permeability enhancers. They are pharmacologically effective and safe, inactive, non-allergenic, and non-irritating. These characteristics ensure their suitability for use without causing adverse effects. Natural compounds are readily available and well tolerated by the body. Studies investigating the structure-activity relationship of natural chemicals have demonstrated significant
enhancer effects. By understanding the connection between chemical composition and
enhancer activity, researchers can identify effective natural compounds for improving drug penetration. In conclusion, current research focuses on utilizing natural compounds as permeability enhancers in transdermal therapy systems. These substances offer safety, non-toxicity, pharmacological inactivity, and non-irritation. Through structure-activity relationship investigations, promising advancements have been made in enhancing drug delivery. Using natural compounds holds enormous potential for improving the penetration of trans-dermally delivered medications.